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The modulatory effects of rTMS can be adjusted by changing the repetition patterns. Theta-burst magnetic stimulation (TBS) is a magnetic stimulation pattern that can induce long-lasting modulatory effects with a short stimulation period. However, its effects on auditory brain regions remain unclear because of a lack of animal studies in which invasive techniques allow for a detailed exploration of the underlying neural mechanisms. In the current study, we investigated the effects of TBS on the C57BL\/6J mouse auditory cortex using a custom-built 7\u2005mm magnetic stimulation coil. Extracellular recordings were made before, during, and after the application of intermittent TBS (iTBS), continuous TBS (cTBS), or sham stimulation. Local field potential amplitudes were increased for 5\u201320\u2005min post-iTBS compared with the sham condition and were decreased at 10\u2005min post-cTBS compared with the sham condition. The bidirectional modulatory effects observed in our study are consistent with previous findings from other brain regions. Additionally, multiunit activities were significantly altered in cortical layers 2\/3 and 4 but not layer 5, indicating that the modulatory effects were localized to the surface region of the auditory cortex. Interestingly, in the iTBS group, the amplitude of average spike waveforms increased with a 15\u2005min delay. Our findings provide physiological evidence of TBS modulation of the rodent auditory cortex and may guide future research seeking to optimize rTMS for modulating hearing abilities.<\/jats:p>","DOI":"10.1523\/eneuro.0577-24.2025","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T17:50:21Z","timestamp":1744912221000},"page":"ENEURO.0577-24.2025","source":"Crossref","is-referenced-by-count":1,"title":["Localized Theta-Burst Magnetic Stimulation Induces Bidirectional Neural Modulation in the Mouse Auditory Cortex In 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