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Accordingly, brain\u2013handedness associations are well documented. However, laterality preferences extend beyond handedness to include other limbs, such as footedness and eyedness. Despite these distinctions, brain\u2013footedness and brain\u2013eyedness associations using resting-state functional connectomes remain largely unexplored. We utilize two large datasets, the Human Connectome Project-Development (HCP-D) and Human Connectome Project-Aging (HCP-A), to study the associations between sidedness (i.e., handedness, footedness, and eyedness) and whole-brain functional connectomes. While hand and foot preferences were correlated significantly, they explained &lt;40% of the variance, suggesting some distinctions between measures. For both cohorts, significant associations between handedness connectivity were observed [<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, network-based statistics (NBS) corrected]. Notable patterns include increased connectivity for left-handedness in the posterior temporal areas and right-handedness in cerebellar regions. In contrast, significant associations between footedness and handedness connectivity were observed only in the HCP-A (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, NBS corrected) and not the HCP-D. No significant associations between eyedness and connectivity were observed for either group. Finally, we compared the effect size between brain\u2013handedness and brain\u2013footedness associations. A greater difference was found in the HCP-D. The two cohorts primarily differed in edge distribution in the prefrontal lobe, temporal lobe, and cerebellum. Overall, in adults, brain\u2013handedness and brain\u2013footedness associations were similar. However, in children to adolescents, brain\u2013handedness and brain\u2013footedness associations diverge, suggesting a developmental shift. Characterizing sidedness associations with whole-brain connectomes may provide important insights into understanding the motor and visual systems, rehabilitation and occupational therapy, and benchmarking normative variations in the connectome.<\/jats:p>","DOI":"10.1523\/eneuro.0580-24.2025","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T13:50:20Z","timestamp":1749131420000},"page":"ENEURO.0580-24.2025","source":"Crossref","is-referenced-by-count":2,"title":["Functional Connectome Correlates of Laterality Preferences: Insights into Hand, Foot, and Eye Dominance across the 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