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In this study, we demonstrate that pancreatitis-associated protein (PAP)-III is a macrophage chemoattractant that is induced in and released from injured nerves.\n                    <jats:italic>In vitro<\/jats:italic>\n                    experiments revealed that PAP-III possessed a strong macrophage chemoattractant activity that was comparable with that of monocyte chemoattractant protein-1. In addition, gene knockdown via adenovirus-mediated small interference RNA expression in isolated sciatic nerves successfully suppressed PAP-III expression and its macrophage chemoattractant activity. Furthermore, overexpression or knockdown of the PAP-III gene in crushed sciatic nerves in rats resulted in acceleration or retardation of macrophage recruitment and subsequent nerve regeneration, respectively. Collectively, our results demonstrate that PAP-III is a novel macrophage chemoattractant that is involved in peripheral nerve regeneration and further provide new insights into Schwann cell\u2013macrophage interactions and therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.0023-06.2006","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T15:24:54Z","timestamp":1152717894000},"page":"7460-7467","source":"Crossref","is-referenced-by-count":62,"title":["Pancreatitis-Associated Protein-III Is a Novel Macrophage Chemoattractant Implicated in Nerve Regeneration"],"prefix":"10.1523","volume":"26","author":[{"given":"Kazuhiko","family":"Namikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinobu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"2023041303192946000_26.28.7460.1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1995.1095"},{"key":"2023041303192946000_26.28.7460.2","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1523\/JNEUROSCI.19-05-01708.1999","volume":"19","year":"(1999)","journal-title":"J Neurosci"},{"key":"2023041303192946000_26.28.7460.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF01148493"},{"key":"2023041303192946000_26.28.7460.4","doi-asserted-by":"crossref","first-page":"6713","DOI":"10.1523\/JNEUROSCI.18-17-06713.1998","volume":"18","year":"(1998)","journal-title":"J Neurosci"},{"key":"2023041303192946000_26.28.7460.5","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0318"},{"key":"2023041303192946000_26.28.7460.6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/bj3070009","volume":"307","year":"(1995)","journal-title":"Biochem J"},{"key":"2023041303192946000_26.28.7460.7","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90009-4"},{"key":"2023041303192946000_26.28.7460.8","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1164"},{"key":"2023041303192946000_26.28.7460.9","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2002.6387"},{"key":"2023041303192946000_26.28.7460.10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4483-03.2004"},{"key":"2023041303192946000_26.28.7460.11","doi-asserted-by":"crossref","unstructured":"Hughes PM, Perry VH (2000) The role of macrophages in degeneration and regeneration in the peripheral nervous system. 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