{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:12:37Z","timestamp":1793794357794,"version":"4.6.1"},"reference-count":61,"publisher":"Society for Neuroscience","issue":"13","license":[{"start":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T00:00:00Z","timestamp":1190937600000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2007,3,28]]},"abstract":"<jats:p>\n                    A defect in microtubule (MT)-based transport contributes to the neuronal toxicity observed in Huntington's disease (HD). Histone deacetylase (HDAC) inhibitors show neuroprotective effects in this devastating neurodegenerative disorder. We report here that HDAC inhibitors, including trichostatin A (TSA), increase vesicular transport of brain-derived neurotrophic factor (BDNF) by inhibiting HDAC6, thereby increasing acetylation at lysine 40 of \u03b1-tubulin. MT acetylation\n                    <jats:italic>in vitro<\/jats:italic>\n                    and in cells causes the recruitment of the molecular motors dynein and kinesin-1 to MTs. In neurons, acetylation at lysine 40 of \u03b1-tubulin increases the flux of vesicles and the subsequent release of BDNF. We show that tubulin acetylation is reduced in HD brains and that TSA compensates for the transport- and release-defect phenotypes that are observed in disease. Our findings reveal that HDAC6 inhibition and acetylation at lysine 40 of \u03b1-tubulin may be therapeutic targets of interest in disorders such as HD in which intracellular transport is altered.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.0037-07.2007","type":"journal-article","created":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T12:53:26Z","timestamp":1175086406000},"page":"3571-3583","source":"Crossref","is-referenced-by-count":734,"title":["Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation"],"prefix":"10.1523","volume":"27","author":[{"given":"Jim P.","family":"Dompierre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette D.","family":"Godin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte C.","family":"Charrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice P.","family":"Cordeli\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Humbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Saudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2007,3,28]]},"reference":[{"key":"2023041303242356000_27.13.3571.1","doi-asserted-by":"publisher","DOI":"10.1038\/39885"},{"key":"2023041303242356000_27.13.3571.2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3920-03.2004"},{"key":"2023041303242356000_27.13.3571.3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0076-6879(98)98017-X","article-title":"Purification of dynactin and dynein from brain tissue","volume":"298","author":"Bingham","year":"1998","journal-title":"Methods Enzymol"},{"key":"2023041303242356000_27.13.3571.4","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1989"},{"key":"2023041303242356000_27.13.3571.5","doi-asserted-by":"crossref","unstructured":"Butowt R von Bartheld CS (2007) Conventional kinesin-I motors participate in the anterograde axonal transport of neurotrophins in the visual system. 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