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Neural mechanisms for the development and maintenance of allodynia have been investigated in the spinal cord, brainstem, thalamus, and forebrain, but manipulations of these regions rarely produce lasting effects. We found that long-term alleviation of allodynic manifestations is produced by discreetly lesioning a newly discovered somatosensory representation in caudal granular insular cortex (CGIC) in the rat, either before or after a chronic constriction injury of the sciatic nerve. However, CGIC lesions alone have no effect on normal mechanical stimulus thresholds. In addition, using electrophysiological techniques, we reveal a corticospinal loop that could be the anatomical source of the influence of CGIC on allodynia.<\/jats:p>","DOI":"10.1523\/jneurosci.0076-11.2011","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T12:49:38Z","timestamp":1303908578000},"page":"6317-6328","source":"Crossref","is-referenced-by-count":74,"title":["Caudal Granular Insular Cortex Is Sufficient and Necessary for the Long-Term Maintenance of Allodynic Behavior in the Rat Attributable to Mononeuropathy"],"prefix":"10.1523","volume":"31","author":[{"given":"Alexander M.","family":"Benison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhiy","family":"Chumachenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline 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