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Further insight into the relationship between tremor onset and the onset of coherence could pave the way to more efficient deep brain stimulation (DBS) algorithms for tremor. We studied 10 severely affected ET patients (six females, four males) during surgery for DBS-electrode implantation and simultaneously recorded local field potentials (LFPs) and surface electromyographic signals (EMGs) from the extensor and flexor muscles of the contralateral forearm during its elevation. The temporal relationship between the onset of significant wavelet cross spectrum (WCS) and tremor onset was determined. Moreover, we examined the influence of electrode location within one recording depth on this latency and the coincidence of coherence and tremor for depths with strong overall coherence (\u201ctremor clusters\u201d) and those without. Data analysis revealed tremor onset occurring 220 \u00b1 460 ms before the start of significant LFP-EMG coherence. Furthermore, we could detect an anterolateral gradient of WCS onset within one recording depth. Finally, the coincidence of tremor and coherence was significantly higher in tremor clusters. We conclude that tremor onset precedes the beginning of coherence. Besides, within one recording depth there is a spread of the tremor signal. This reflects the importance of somatosensory feedback for ET and questions the suitability of thalamomuscular coherence as a biomarker for \u201cclosed-loop\u201d DBS systems to prevent tremor emergence.<\/jats:p>","DOI":"10.1523\/jneurosci.0087-14.2014","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T16:57:56Z","timestamp":1413997076000},"page":"14475-14483","source":"Crossref","is-referenced-by-count":60,"title":["Thalamomuscular Coherence in Essential Tremor: Hen or Egg in the Emergence of Tremor?"],"prefix":"10.1523","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-1959","authenticated-orcid":false,"given":"David J.","family":"Pedrosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1274-6155","authenticated-orcid":false,"given":"Eva-Lotte","family":"Quatuor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Reck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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