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Moreover, DA depletion can attenuate dopaminergic cell loss\n                    <jats:italic>in vitro<\/jats:italic>\n                    . To test the contribution of DA to SN impairment\n                    <jats:italic>in vivo<\/jats:italic>\n                    , we used DA-deficient mice, which lack the enzyme tyrosine hydroxylase in dopaminergic cells, and mice pharmacologically depleted of DA by \u03b1-methyl-\n                    <jats:italic>p<\/jats:italic>\n                    -tyrosine pretreatment. Mice were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a toxin that produces parkinsonian pathology in humans, nonhuman primates, and rodents. In contrast to\n                    <jats:italic>in vitro<\/jats:italic>\n                    results, genetic or pharmacologic DA depletion did not attenuate loss of dopaminergic neurons in the SN or dopaminergic neuron terminals in the striatum. These results suggest that DA does not contribute to acute MPTP toxicity\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.0130-05.2005","type":"journal-article","created":{"date-parts":[[2005,10,12]],"date-time":"2005-10-12T14:17:54Z","timestamp":1129126674000},"page":"9428-9433","source":"Crossref","is-referenced-by-count":28,"title":["Dopamine Depletion Does Not Protect against Acute 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Toxicity\n                    <i>In Vivo<\/i>"],"prefix":"10.1523","volume":"25","author":[{"given":"Daphne M.","family":"Hasbani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco A.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Palmiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"O'Malley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2005,10,12]]},"reference":[{"key":"2023041303151028000_25.41.9428.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00180-8"},{"key":"2023041303151028000_25.41.9428.2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7659"},{"key":"2023041303151028000_25.41.9428.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0731127.x"},{"key":"2023041303151028000_25.41.9428.4","doi-asserted-by":"publisher","DOI":"10.1038\/81834"},{"key":"2023041303151028000_25.41.9428.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(01)00003-X"},{"key":"2023041303151028000_25.41.9428.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181356498"},{"key":"2023041303151028000_25.41.9428.7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0169-328X(99)00235-1","volume":"73","year":"1999","journal-title":"Brain Res Mol Brain Res"},{"key":"2023041303151028000_25.41.9428.8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/978-1-4615-0667-6_61","volume":"500","year":"2001","journal-title":"Adv Exp Med Biol"},{"key":"2023041303151028000_25.41.9428.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02595.x"},{"key":"2023041303151028000_25.41.9428.10","doi-asserted-by":"crossref","first-page":"8955","DOI":"10.1523\/JNEUROSCI.23-26-08955.2003","volume":"23","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303151028000_25.41.9428.11","first-page":"17","volume":"48","year":"1985","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"2023041303151028000_25.41.9428.12","first-page":"1000","volume":"270","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"2023041303151028000_25.41.9428.13","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200103000-00001"},{"key":"2023041303151028000_25.41.9428.14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.5.1956"},{"key":"2023041303151028000_25.41.9428.15","doi-asserted-by":"publisher","DOI":"10.1016\/1055-8330(95)90015-2"},{"key":"2023041303151028000_25.41.9428.16","unstructured":"Kalbfleisch JD, Prentice RL (1980) The statistical analysis of failure time data. 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