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We identified a transcript with high sequence similarity to crustacean cardioactive peptide (CCAP) receptors in insects and mammalian neuropeptide S receptors. This transcript was expressed throughout the nervous system, consistent with the role of CCAP in a range of different behaviors. In the STG, single-cell qPCR showed expression in only a subset of neurons. This subset had previously been shown to respond to CCAP with the activation of a modulator-activated inward current (<jats:italic>I<\/jats:italic><jats:sub>MI<\/jats:sub>), with one exception. In the one cell type that showed expression but no<jats:italic>I<\/jats:italic><jats:sub>MI<\/jats:sub>responses, we found CCAP modulation of synaptic currents. Expression levels within STG neuron types were fairly variable, but significantly different between some neuron types. We tested the magnitude and concentration dependence of<jats:italic>I<\/jats:italic><jats:sub>MI<\/jats:sub>responses to CCAP application in two identified neurons, the lateral pyloric (LP) and the inferior cardiac (IC) neurons. LP had several-fold higher expression and showed larger current responses. It also was more sensitive to low CCAP concentrations and showed saturation at lower concentrations, as sigmoid fits showed smaller EC<jats:sub>50<\/jats:sub>values and steeper slopes. In addition, occlusion experiments with proctolin, a different neuropeptide converging onto<jats:italic>I<\/jats:italic><jats:sub>MI<\/jats:sub>, showed that saturating concentrations of CCAP activated all available<jats:italic>I<\/jats:italic><jats:sub>MI<\/jats:sub>in LP, but only approximately two-thirds in IC, the neuron with lower receptor transcript expression. The implications of these findings for comodulation are discussed.<\/jats:p>","DOI":"10.1523\/jneurosci.0171-15.2015","type":"journal-article","created":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T16:33:04Z","timestamp":1430325184000},"page":"6786-6800","source":"Crossref","is-referenced-by-count":46,"title":["Neuropeptide Receptor Transcript Expression Levels and Magnitude of Ionic Current Responses Show Cell Type-Specific Differences in a Small Motor Circuit"],"prefix":"10.1523","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6906-2221","authenticated-orcid":false,"given":"Veronica 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