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Neurosci."],"accepted":{"date-parts":[[2024,8,7]]},"published-print":{"date-parts":[[2024,9,11]]},"abstract":"<jats:p>The act of recalling memories can paradoxically lead to the forgetting of other associated memories, a phenomenon known as retrieval-induced forgetting (RIF). Inhibitory control mechanisms, primarily mediated by the prefrontal cortex, are thought to contribute to RIF. In this study, we examined whether stimulating the medial prefrontal cortex (mPFC) with transcranial direct current stimulation modulates RIF and investigated the associated electrophysiological correlates. In a randomized study, 50 participants (27 males and 23 females) received either real or sham stimulation before performing retrieval practice on target memories. After retrieval practice, a final memory test to assess RIF was administered. We found that stimulation selectively increased the retrieval accuracy of competing memories, thereby decreasing RIF, while the retrieval accuracy of target memories remained unchanged. The reduction in RIF was associated with a more pronounced beta desynchronization within the left dorsolateral prefrontal cortex (left-DLPFC), in an early time window (&lt;500\u2005ms) after cue onset during retrieval practice. This led to a stronger beta desynchronization within the parietal cortex in a later time window, an established marker for successful memory retrieval. Together, our results establish the causal involvement of the mPFC in actively suppressing competing memories and demonstrate that while forgetting arises as a consequence of retrieving specific memories, these two processes are functionally independent. Our findings suggest that stimulation potentially disrupted inhibitory control processes, as evidenced by reduced RIF and stronger beta desynchronization in fronto-parietal brain regions during memory retrieval, although further research is needed to elucidate the specific mechanisms underlying this effect.<\/jats:p>","DOI":"10.1523\/jneurosci.0189-24.2024","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T13:50:11Z","timestamp":1723729811000},"page":"e0189242024","source":"Crossref","is-referenced-by-count":12,"title":["Medial Prefrontal Cortex Stimulation Reduces Retrieval-Induced Forgetting via Fronto-parietal Beta Desynchronization"],"prefix":"10.1523","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-9839","authenticated-orcid":false,"given":"Ahsan","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Hang Eden","family":"Ti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Crespo Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Kai-Yu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"2025111207300579000_44.37.e0189242024.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jml.2003.08.006"},{"key":"2025111207300579000_44.37.e0189242024.2","doi-asserted-by":"publisher","DOI":"10.1037\/0278-7393.20.5.1063"},{"key":"2025111207300579000_44.37.e0189242024.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-psych-072720-094140","article-title":"Active forgetting: adaptation of memory by prefrontal control","volume":"72","author":"Anderson","year":"2020","journal-title":"Annu Rev Psychol"},{"key":"2025111207300579000_44.37.e0189242024.4","doi-asserted-by":"crossref","first-page":"e14087","DOI":"10.14814\/phy2.14087","article-title":"Effects of anodal transcranial direct current stimulation on motor evoked potentials variability in humans","volume":"7","author":"Bashir","year":"2019","journal-title":"Physiol Rep"},{"key":"2025111207300579000_44.37.e0189242024.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.2007.01857.x"},{"key":"2025111207300579000_44.37.e0189242024.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.03.018"},{"key":"2025111207300579000_44.37.e0189242024.7","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz017"},{"key":"2025111207300579000_44.37.e0189242024.8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroimage.2019.05.048","article-title":"A better way to define and describe Morlet wavelets for time-frequency analysis","volume":"199","author":"Cohen","year":"2019","journal-title":"Neuroimage"},{"key":"2025111207300579000_44.37.e0189242024.9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1711-21.2022"},{"key":"2025111207300579000_44.37.e0189242024.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.10.009"},{"key":"2025111207300579000_44.37.e0189242024.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.694"},{"key":"2025111207300579000_44.37.e0189242024.12","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.20020"},{"key":"2025111207300579000_44.37.e0189242024.13","doi-asserted-by":"publisher","DOI":"10.3758\/CABN.10.3.329"},{"key":"2025111207300579000_44.37.e0189242024.14","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00074"},{"key":"2025111207300579000_44.37.e0189242024.15","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0696-22.2023"},{"key":"2025111207300579000_44.37.e0189242024.16","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4889-13.2014"},{"key":"2025111207300579000_44.37.e0189242024.17","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1007\/s00429-023-02667-2","article-title":"Modulation of resting-state networks following repetitive transcranial alternating current stimulation of the dorsolateral prefrontal cortex","volume":"228","author":"Khan","year":"2023","journal-title":"Brain Struct Funct"},{"key":"2025111207300579000_44.37.e0189242024.18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neures.2022.03.006","article-title":"Impact of anodal high-definition transcranial direct current stimulation of medial prefrontal cortex on Stroop task performance and its electrophysiological correlates. 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