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NPCs derived from the subventricular zone (SVZ-NPCs) were also included in the study as a reference from a distant inflammatory site. We also investigated the transcriptional and functional difference between the SC-NPCs and SVZ-NPCs during homeostatic conditions. NPCs were isolated and propagated from the SVZ and cervical, thoracic, and caudal regions of the SC from naive rats and rats subjected to EAE. Using Affymetrix microarray analyses, the global transcriptome was measured in the different NPC populations. These analyses were paralleled by NPC differentiation studies. Assessment of basal transcriptional and functional differences between NPC populations in naive rat revealed a higher neurogenic potential in SVZ-NPCs compared with SC-NPCs. Conversely, during EAE, the neurogenicity of the SC-NPCs was increased while their gliogenicity was decreased. We detected an overall increase of inflammation and neurodegeneration-related genes while the developmentally related profile was decreased. Among the decreased functions, we isolated a gliogenic signature that was confirmed by differentiation assays where the SC-NPCs from EAE generated fewer oligodendrocytes and astrocytes but more neurons than control cultures. In summary, NPCs displayed differences in fate-regulating genes and differentiation potential depending on their rostrocaudal origin. Inflammatory conditions downregulated gliogenicity in SC-NPCs, promoting neurogenicity. These findings give important insight into neuroinflammatory diseases and the mechanisms influencing NPC plasticity during these conditions.<\/jats:p>","DOI":"10.1523\/jneurosci.0231-14.2014","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T22:26:44Z","timestamp":1410215204000},"page":"11571-11582","source":"Crossref","is-referenced-by-count":13,"title":["Change of Fate Commitment in Adult Neural Progenitor Cells Subjected to Chronic Inflammation"],"prefix":"10.1523","volume":"34","author":[{"given":"Ruxandra","family":"Covacu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Perez Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Arvidsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lou","family":"Brundin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"key":"2023041304124665000_34.35.11571.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.10.042"},{"key":"2023041304124665000_34.35.11571.2","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.4049\/jimmunol.153.10.4349","article-title":"Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB\/H mice","volume":"153","author":"Amor","year":"1994","journal-title":"J Immunol"},{"key":"2023041304124665000_34.35.11571.3","doi-asserted-by":"crossref","first-page":"7913","DOI":"10.1523\/JNEUROSCI.19-18-07913.1999","article-title":"Negative regulation of oligodendrocyte differentiation by galactosphingolipids","volume":"19","author":"Bansal","year":"1999","journal-title":"J Neurosci"},{"key":"2023041304124665000_34.35.11571.4","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf662"},{"key":"2023041304124665000_34.35.11571.5","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01035"},{"key":"2023041304124665000_34.35.11571.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5464.344"},{"key":"2023041304124665000_34.35.11571.7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.7.1248"},{"key":"2023041304124665000_34.35.11571.8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1750-3639.2003.tb00031.x","article-title":"Neural stem cells: a potential source for remyelination in neuroinflammatory disease","volume":"13","author":"Brundin","year":"2003","journal-title":"Brain Pathol"},{"key":"2023041304124665000_34.35.11571.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.10.006"},{"key":"2023041304124665000_34.35.11571.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.028"},{"key":"2023041304124665000_34.35.11571.11","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1523\/JNEUROSCI.21-13-04740.2001","article-title":"Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro","volume":"21","author":"Calaora","year":"2001","journal-title":"J Neurosci"},{"key":"2023041304124665000_34.35.11571.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1990.tb01228.x"},{"key":"2023041304124665000_34.35.11571.13","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0640"},{"key":"2023041304124665000_34.35.11571.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04563.x"},{"key":"2023041304124665000_34.35.11571.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80783-7"},{"key":"2023041304124665000_34.35.11571.16","doi-asserted-by":"crossref","unstructured":"Duncan DT Prodduturi N Zhang B (2010) WebGestalt2: an updated and expanded version of the Web-based Gene Set Analysis Toolkit. 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