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Moreover, a parcellation of the monkey OFC into two subdivisions has been suggested based on its intrinsic anatomical connections. However, in humans, little is known about any functional subdivisions of the OFC except for a rather coarse medial\/lateral distinction. Here, we used resting-state fMRI in combination with unsupervised clustering techniques to investigate whether OFC subdivisions can be revealed based on their functional connectivity profiles with other brain regions. Examination of different cluster solutions provided support for a parcellation into two parts as observed in monkeys, but it also highlighted a much finer hierarchical clustering of the orbital surface. Specifically, we identified (1) a medial, (2) a posterior-central, (3) a central, and (4\u20136) three lateral clusters spanning the anterior\u2013posterior gradient. Consistent with animal tracing studies, these OFC clusters were connected to other cortical regions such as prefrontal, temporal, and parietal cortices but also subcortical areas in the striatum and the midbrain. These connectivity patterns provide important implications for identifying specific functional roles of OFC subdivisions for reward processing, learning, and decision making. Moreover, this parcellation schema can provide guidance to report results in future studies.<\/jats:p>","DOI":"10.1523\/jneurosci.0257-12.2012","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T12:53:49Z","timestamp":1335963229000},"page":"6240-6250","source":"Crossref","is-referenced-by-count":285,"title":["Connectivity-Based Parcellation of the Human Orbitofrontal Cortex"],"prefix":"10.1523","volume":"32","author":[{"given":"Thorsten","family":"Kahnt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke J.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung Q","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Heinzle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Dylan","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2012,5,2]]},"reference":[{"key":"2023041303561339000_32.18.6240.1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1554-07.2007"},{"key":"2023041303561339000_32.18.6240.2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902860306"},{"key":"2023041303561339000_32.18.6240.3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3328-08.2009"},{"key":"2023041303561339000_32.18.6240.4","doi-asserted-by":"publisher","DOI":"10.1038\/nn1954"},{"key":"2023041303561339000_32.18.6240.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911855107"},{"key":"2023041303561339000_32.18.6240.6","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"2023041303561339000_32.18.6240.7","unstructured":"Brodmann K (1909) Vergleichende lokalisationslehre der grosshirnrinde: in ihren principien dargestellt auf grund des zellenbaues (Johann Ambrosius Barth Verlag, Leipzig, Germany)."},{"key":"2023041303561339000_32.18.6240.8","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903460305"},{"key":"2023041303561339000_32.18.6240.9","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903630408"},{"key":"2023041303561339000_32.18.6240.10","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903630409"},{"key":"2023041303561339000_32.18.6240.11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960722)371:2<179::AID-CNE1>3.0.CO;2-#"},{"key":"2023041303561339000_32.18.6240.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.049"},{"key":"2023041303561339000_32.18.6240.13","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902870402"},{"key":"2023041303561339000_32.18.6240.14","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902870403"},{"key":"2023041303561339000_32.18.6240.15","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.220"},{"key":"2023041303561339000_32.18.6240.16","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"2023041303561339000_32.18.6240.17","doi-asserted-by":"crossref","unstructured":"Chang LJ Yarkoni T Khaw MW Sanfey AG (2012) Decoding the role of the insula in human cognition: functional parcellation and large-scale reverse inference. 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