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At 12-months-old, CSF levels of CRF were measured and HPA axis activity was characterized by examining diurnal cortisol rhythm and response to pharmacological challenges. Compared with controls, Neo-A animals showed higher cortisol secretion throughout the day, and Neo-A females also showed higher CRF levels. Hypersecretion of basal cortisol, in conjunction with blunted pituitary-adrenal responses to CRF challenge, suggest HPA axis hyperactivity caused by increased CRF hypothalamic drive leading to downregulation of pituitary CRF receptors in Neo-A animals. This interpretation is supported by the increased CRF CSF levels, suggesting that Neo-A damage resulted in central CRF systems overactivity. Neo-A animals also exhibited enhanced glucocorticoid negative feedback, as reflected by an exaggerated cortisol suppression following dexamethasone administration, indicating an additional effect on glucocorticoid receptor (GR) function. Together these data demonstrate that early amygdala damage alters the typical development of the primate HPA axis resulting in increased rather than decreased activity, presumably via alterations in central CRF and GR systems in neural structures that control its activity. Thus, in contrast to evidence that the amygdala stimulates both CRF and HPA axis systems in the adult, our data suggest an opposite, inhibitory role of the amygdala on the HPA axis during early development, which fits with emerging literature on \u201cdevelopmental switches\u201d in amygdala function and connectivity with other brain areas.<\/jats:p>","DOI":"10.1523\/jneurosci.0269-14.2014","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T22:26:19Z","timestamp":1410215179000},"page":"11452-11460","source":"Crossref","is-referenced-by-count":27,"title":["Neonatal Amygdala Lesions Lead to Increased Activity of Brain CRF Systems and Hypothalamic-Pituitary-Adrenal Axis of Juvenile Rhesus Monkeys"],"prefix":"10.1523","volume":"34","author":[{"given":"Jessica","family":"Raper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon 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