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Burst firing of STN neurons may be driven by rebound depolarization after barrages of GABA<jats:sub>A<\/jats:sub>receptor (GABA<jats:sub>A<\/jats:sub>R)-mediated IPSPs arising from pallidal fibers. To determine the conditions under which pallidosubthalamic transmission activates these and other postsynaptic GABARs, a parasagittal mouse brain slice preparation was developed in which pallidosubthalamic connections were preserved. Intact connectivity was first confirmed through the injection of a neuronal tracer into the GP. Voltage-clamp and gramicidin-based perforated-patch current-clamp recordings were then used to study the relative influences of GABA<jats:sub>A<\/jats:sub>R- and GABA<jats:sub>B<\/jats:sub>R-mediated pallidosubthalamic transmission on STN neurons. Spontaneous phasic, but not tonic, activation of postsynaptic GABA<jats:sub>A<\/jats:sub>Rs reduced the frequency and disrupted the rhythmicity of autonomous firing in STN neurons. However, postsynaptic GABA<jats:sub>B<\/jats:sub>Rs were only sufficiently activated to impact STN firing when pallidosubthalamic transmission was elevated or pallidal fibers were synchronously activated by electrical stimulation. In a subset of neurons, rebound burst depolarizations followed high-frequency, synchronous stimulation of pallidosubthalamic fibers. Although GABA<jats:sub>B<\/jats:sub>R-mediated hyperpolarization was itself sufficient to generate rebound bursts, coincident activation of postsynaptic GABA<jats:sub>A<\/jats:sub>Rs produced longer and more intense burst firing. These findings elucidate a novel route through which burst activity can be generated in the STN, and suggest that GABARs on STN neurons could act in a synergistic manner to generate abnormal burst activity in PD.<\/jats:p>","DOI":"10.1523\/jneurosci.0450-05.2005","type":"journal-article","created":{"date-parts":[[2005,7,6]],"date-time":"2005-07-06T23:53:23Z","timestamp":1120694003000},"page":"6304-6315","source":"Crossref","is-referenced-by-count":86,"title":["Globus Pallidus Neurons Dynamically Regulate the Activity Pattern of Subthalamic Nucleus Neurons through the Frequency-Dependent Activation of Postsynaptic GABA<sub>A<\/sub>and GABA<sub>B<\/sub>Receptors"],"prefix":"10.1523","volume":"25","author":[{"given":"Nicholas E.","family":"Hallworth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark 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