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Neurosci."],"published-print":{"date-parts":[[2024,2,14]]},"abstract":"<jats:p>It is poorly known how A\u03b2 and tau accumulations associate at the spatiotemporal level in the in vivo human brain to impact cognitive changes in older adults prior to AD symptoms onset. In this study, we used a graph theory-based spatiotemporal analysis to characterize the cortical patterns of A\u03b2 and tau deposits and their relationship with cognitive changes in the Harvard Aging Brain Study (HABS) cohort. We found that the temporal accumulations of interlinked A\u03b2 and tau pathology display distinctive spatiotemporal correlations associated with early cognitive decline. Notably, we observed that baseline A\u03b2 deposits\u2014Thal amyloid phase \u2161\u2014related to future increase of tau deposits, Braak stages \u2160\u2013\u2163, both displaying linkage to the decline in multi-domain cognitive scores. We also found unimodal tau-to-tau and cognitive impairment associations in broad areas of Braak stages \u2160\u2013\u2163. The unimodal A\u03b2-to-A\u03b2 progressions were not associated with cognitive changes. Our results revealed a multifaceted correlation of the spatiotemporal A\u03b2 and tau associations with cognitive decline over time, in which tau-to-tau and tau\u2013A\u03b2 interactions, and not A\u03b2 independently, might be critical contributors to clinical trajectories toward AD in older adults.<\/jats:p>","DOI":"10.1523\/jneurosci.0488-23.2023","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T18:50:15Z","timestamp":1703098215000},"page":"e0488232023","source":"Crossref","is-referenced-by-count":9,"title":["Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in 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