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Neurosci."],"published-print":{"date-parts":[[2022,12,7]]},"abstract":"<jats:p>Nociceptive signals interact with various regions of the brain, including those involved in physical sensation, reward, cognition, and emotion. Emerging evidence points to a role of nociception in the modulation of the mesolimbic reward system. The mechanism by which nociception affects dopamine (DA) signaling and reward is unclear. The lateral hypothalamus (LH) and the lateral habenula (LHb) receive somatosensory inputs and are structurally connected with the mesolimbic DA system. Here, we show that the LH\u2013LHb pathway is necessary for nociceptive modulation of this system using male Sprague Dawley rats. Our extracellular single-unit recordings and head-mounted microendoscopic calcium imaging revealed that nociceptive stimulation by tail pinch excited LHb and LH neurons, which was inhibited by chemical lesion of the LH. Tail pinch increased activity of GABA neurons in ventral tegmental area, decreased the extracellular DA level in the nucleus accumbens ventrolateral shell in intact rats, and reduced cocaine-increased DA concentration, which was blocked by disruption of the LH. Furthermore, tail pinch attenuated cocaine-induced locomotor activity, 22 and 50 kHz ultrasonic vocalizations, and reinstatement of cocaine-seeking behavior, which was inhibited by chemogenetic silencing of the LH\u2013LHb pathway. Our findings suggest that nociceptive stimulation recruits the LH\u2013LHb pathway to inhibit mesolimbic DA system and drug reinstatement.<\/jats:p><jats:p><jats:bold>SIGNIFICANCE STATEMENT<\/jats:bold>The LHb and the LH have been implicated in processing nociceptive signals and modulating DA release in the mesolimbic DA system. Here, we show that the LH\u2013LHb pathway is critical for nociception-induced modulation of mesolimbic DA release and cocaine reinstatement. Nociceptive stimulation alleviates extracellular DA release in the mesolimbic DA system, cocaine-induced psychomotor activities, and reinstatement of cocaine-seeking behaviors through the LH\u2013LHb pathway. These findings provide novel evidence for sensory modulation of the mesolimbic DA system and drug addiction.<\/jats:p>","DOI":"10.1523\/jneurosci.0577-22.2022","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T12:28:43Z","timestamp":1667219323000},"page":"9180-9192","source":"Crossref","is-referenced-by-count":12,"title":["Nociceptive Stimuli Activate the Hypothalamus\u2013Habenula Circuit to Inhibit the Mesolimbic Reward System and Cocaine-Seeking Behaviors"],"prefix":"10.1523","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-8779","authenticated-orcid":false,"given":"Soo Min","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han 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