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Thirty subjects were involved in the study; 15 performed an audiovisual paired-association learning task, and the remainder completed a control visuo-visual task. Each trial consisted of the successive presentation of a pair of stimuli. Subjects were asked to identify predefined audiovisual or visuo-visual pairs by trial and error. Feedback for each trial was given regardless of whether the response was correct or incorrect. During the delay period, several areas showed an increase in the MRI signal as learning proceeded: crossmodal activity increased in unimodal areas corresponding to visual or auditory areas, and polymodal responses increased in the occipitotemporal junction and parahippocampal gyrus. This pattern was not observed in the visuo-visual intramodal paired-association learning task, suggesting that crossmodal associations might be formed by binding unimodal sensory areas via polymodal regions. In both the audiovisual and visuo-visual tasks, the MRI signal in the superior temporal sulcus (STS) in response to the second stimulus and feedback peaked during the early phase of learning and then decreased, indicating that the STS might be key to the creation of paired associations, regardless of stimulus type. In contrast to the activity changes in the regions discussed above, there was constant activity in the frontoparietal circuit during the delay period in both tasks, implying that the neural substrates for the formation and storage of paired associates are distinct from working memory circuits.<\/jats:p>","DOI":"10.1523\/jneurosci.0636-05.2005","type":"journal-article","created":{"date-parts":[[2005,7,6]],"date-time":"2005-07-06T23:53:23Z","timestamp":1120694003000},"page":"6409-6418","source":"Crossref","is-referenced-by-count":88,"title":["Functionally Segregated Neural Substrates for Arbitrary Audiovisual Paired-Association Learning"],"prefix":"10.1523","volume":"25","author":[{"given":"Hiroki C.","family":"Tanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Sadato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2005,7,6]]},"reference":[{"key":"2023041303133096000_25.27.6409.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1736359"},{"key":"2023041303133096000_25.27.6409.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00070-4"},{"key":"2023041303133096000_25.27.6409.3","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(77)90112-1"},{"key":"2023041303133096000_25.27.6409.4","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10866"},{"key":"2023041303133096000_25.27.6409.5","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/11.12.1110"},{"key":"2023041303133096000_25.27.6409.6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1999)8:2\/3<109::AID-HBM7>3.0.CO;2-W"},{"key":"2023041303133096000_25.27.6409.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6410(98)00004-4"},{"key":"2023041303133096000_25.27.6409.8","doi-asserted-by":"crossref","unstructured":"Evans AC, Kamber M, Collins DL, MacDonald D (1994) An MRI-based probalistic atlas of neuroanatomy. 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