{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:31:38Z","timestamp":1793244698032,"version":"4.5.0"},"reference-count":45,"publisher":"Society for Neuroscience","issue":"39","license":[{"start":{"date-parts":[[2027,3,30]],"date-time":"2027-03-30T00:00:00Z","timestamp":1806364800000},"content-version":"vor","delay-in-days":211,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"funder":[{"name":"MOST | National Natural Science Foundation of China","award":["32100784"],"award-info":[{"award-number":["32100784"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"JST | Jiangsu Natural Science Foundation | Basic Research Program of Jiangsu Province","award":["BK20221458"],"award-info":[{"award-number":["BK20221458"]}]}],"content-domain":{"domain":["jneurosci.org"],"crossmark-restriction":true},"short-container-title":["J. Neurosci."],"accepted":{"date-parts":[[2026,8,26]]},"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:p>\n                    Neural pruning optimizes the structure of neural circuits by selectively eliminating redundant or weakened synaptic connections, thereby enhancing the precision and efficiency of information transmission. Dendrites of class IV dendritic arborization (C4da) sensory neurons of\n                    <jats:italic>Drosophila<\/jats:italic>\n                    undergo a large-scale pruning process during development. However, it is currently ambiguous whether peripheral glia noncell-autonomously modulate dendritic pruning in C4da neurons by transmitting signals. Here, we show that Unpaired1 (Upd1), a secreted glycoprotein, acts as a glial-originated signaling molecule to promote dendritic pruning during development in both male and female\n                    <jats:italic>Drosophila<\/jats:italic>\n                    . Our further investigation reveals that downregulation of Domeless (Dome), the receptor of Upd1, in C4da neurons also triggers dendritic pruning defects. Hopscotch (Hop) kinase and transcription factor Stat92E, as downstream factors activated by Upd1 and Dome, similarly facilitate dendritic pruning. Notably, the Upd1 deficiency in glia produces a significant diminishment in JAK\/STAT activity, and reactivation of this signaling in C4da neurons alleviates the dendritic pruning phenotype caused by glial Upd1 deficits. Furthermore, casein kinase II alpha (CK2a), the catalytic subunit of the serine\/threonine protein kinase CK2, acts as a downstream target of the JAK\/STAT and contributes to dendritic pruning. Collectively, we reveal a novel mechanism by which glia-derived Upd1 promotes dendritic pruning in C4da neurons by interacting with neuronal receptor Dome and activating the JAK\/STAT signaling and downstream CK2a.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.0641-26.2026","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:50:25Z","timestamp":1788198625000},"page":"e0641262026","update-policy":"https:\/\/doi.org\/10.1523\/jneurosci.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Glia-Derived Upd1 Promotes Dendritic Remodeling via Neuronal JAK\/Stat-CK2a Signaling"],"prefix":"10.1523","volume":"46","author":[{"given":"Erqian","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1911-8397","authenticated-orcid":false,"given":"Menglong","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"2026102723451155000_46.39.e0641262026.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00244-2"},{"key":"2026102723451155000_46.39.e0641262026.2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02411"},{"key":"2026102723451155000_46.39.e0641262026.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.04.001"},{"key":"2026102723451155000_46.39.e0641262026.4","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2833"},{"key":"2026102723451155000_46.39.e0641262026.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.modgep.2006.08.003"},{"key":"2026102723451155000_46.39.e0641262026.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.10.045"},{"key":"2026102723451155000_46.39.e0641262026.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.12.013"},{"key":"2026102723451155000_46.39.e0641262026.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00524-3"},{"key":"2026102723451155000_46.39.e0641262026.9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205618"},{"key":"2026102723451155000_46.39.e0641262026.10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006089"},{"key":"2026102723451155000_46.39.e0641262026.11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neures.2020.11.010","article-title":"Spatiotemporal regulation of developmental neurite pruning: molecular and cellular insights from Drosophila models","volume":"167","author":"Furusawa","year":"2020","journal-title":"Neurosci Res"},{"key":"2026102723451155000_46.39.e0641262026.12","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S305420"},{"key":"2026102723451155000_46.39.e0641262026.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.03.041"},{"key":"2026102723451155000_46.39.e0641262026.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.11.021"},{"key":"2026102723451155000_46.39.e0641262026.15","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.20.3252"},{"key":"2026102723451155000_46.39.e0641262026.16","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.79461"},{"key":"2026102723451155000_46.39.e0641262026.17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066707"},{"key":"2026102723451155000_46.39.e0641262026.18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507393102"},{"key":"2026102723451155000_46.39.e0641262026.19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135632"},{"key":"2026102723451155000_46.39.e0641262026.20","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113100"},{"key":"2026102723451155000_46.39.e0641262026.21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1202529"},{"key":"2026102723451155000_46.39.e0641262026.22","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2741"},{"key":"2026102723451155000_46.39.e0641262026.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.019"},{"key":"2026102723451155000_46.39.e0641262026.24","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013038"},{"key":"2026102723451155000_46.39.e0641262026.25","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.240059"},{"key":"2026102723451155000_46.39.e0641262026.26","doi-asserted-by":"publisher","DOI":"10.1242\/dev.191155"},{"key":"2026102723451155000_46.39.e0641262026.27","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948843"},{"key":"2026102723451155000_46.39.e0641262026.28","doi-asserted-by":"crossref","first-page":"e1009458","DOI":"10.1371\/journal.pcbi.1009458","article-title":"The information theory of developmental pruning: optimizing global network architectures using local synaptic rules","volume":"17","author":"Scholl","year":"2021","journal-title":"PLoS Comput Biol"},{"key":"2026102723451155000_46.39.e0641262026.29","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1729-6"},{"key":"2026102723451155000_46.39.e0641262026.30","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0334-7"},{"key":"2026102723451155000_46.39.e0641262026.31","first-page":"10.17912\/micropub.biology.000387","article-title":"Endogenous epitope tagging of a JAK\/STAT ligand Unpaired1 in Drosophila","volume":"2021","author":"Takemura","year":"2021","journal-title":"MicroPubl Biol"},{"key":"2026102723451155000_46.39.e0641262026.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.07.040"},{"key":"2026102723451155000_46.39.e0641262026.33","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04558-2"},{"key":"2026102723451155000_46.39.e0641262026.34","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20035"},{"key":"2026102723451155000_46.39.e0641262026.35","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3691"},{"key":"2026102723451155000_46.39.e0641262026.36","doi-asserted-by":"crossref","first-page":"e3003049","DOI":"10.1371\/journal.pbio.3003049","article-title":"Signals from the niche promote distinct modes of translation initiation to control stem cell differentiation and renewal in the Drosophila testis","volume":"23","author":"Wang","year":"2025","journal-title":"PLoS Biol"},{"key":"2026102723451155000_46.39.e0641262026.37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s11658-026-00903-1","article-title":"Ribbon constrains dendritic pruning via actin scaffolding and exocyst complex","volume":"31","author":"Wang","year":"2026","journal-title":"Cell Mol Biol Lett"},{"key":"2026102723451155000_46.39.e0641262026.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.03.035"},{"key":"2026102723451155000_46.39.e0641262026.39","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01928"},{"key":"2026102723451155000_46.39.e0641262026.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.01.020"},{"key":"2026102723451155000_46.39.e0641262026.41","doi-asserted-by":"crossref","unstructured":"Xu W , Wang S , Lv X , Long K , Mo K , Rui M (2026) Patronin facilitates neurite remodeling via epithelial-to-neuronal signaling. Cell Commun Signal. https:\/\/doi.org\/10.1186\/s12964-026-03026-4","DOI":"10.1186\/s12964-026-03026-4"},{"key":"2026102723451155000_46.39.e0641262026.42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814456116"},{"key":"2026102723451155000_46.39.e0641262026.43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13578-026-01532-z","article-title":"Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation in Drosophila","volume":"16","author":"Zhang","year":"2026","journal-title":"Cell Biosci"},{"key":"2026102723451155000_46.39.e0641262026.44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00018-024-05560-1","article-title":"Glial-derived TNF\/eiger signaling promotes somatosensory neurite sculpting","volume":"82","author":"Zheng","year":"2025","journal-title":"Cell Mol Life Sci"},{"key":"2026102723451155000_46.39.e0641262026.45","doi-asserted-by":"publisher","DOI":"10.1242\/dev.163592"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.0641-26.2026","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.0641-26.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:40:15Z","timestamp":1793241615000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.0641-26.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":45,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,30]]},"published-print":{"date-parts":[[2026,9,30]]}},"alternative-id":["10.1523\/JNEUROSCI.0641-26.2026"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.0641-26.2026","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}