{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:11:47Z","timestamp":1790730707321,"version":"4.1.0"},"reference-count":52,"publisher":"Society for Neuroscience","issue":"21","license":[{"start":{"date-parts":[[2006,11,24]],"date-time":"2006-11-24T00:00:00Z","timestamp":1164326400000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,5,24]]},"abstract":"<jats:p>Ca<jats:sup>2+<\/jats:sup>signals are known to be important regulators of neurite outgrowth and steering. Here we show that inhibiting Ca<jats:sup>2+<\/jats:sup>influx through stretch-activated channels using various compounds, including a highly specific peptide isolated from<jats:italic>Grammostola spatulata<\/jats:italic>spider venom (GsMTx4), strongly accelerates the rate of neurite extension on diverse substrata and within the intact spinal cord. Consistent with the presence of stretch-activated channels, we show that Ca<jats:sup>2+<\/jats:sup>influx is triggered by hypotonic solutions, which can be partially blocked by GsMTx4. Finally, chelating local, but not global, Ca<jats:sup>2+<\/jats:sup>signals prevents the acceleration that is normally produced by GsMTx4. Blocking Ca<jats:sup>2+<\/jats:sup>influx through other channel types has little or opposite effects, but release from intracellular stores is required for maximal acceleration. Together, our data suggest that Ca<jats:sup>2+<\/jats:sup>functions at distinct microdomains in growth cones, with influx through mechanosensitive channels acting to inhibit outgrowth in opposition to influx through other plasma membrane channels and release from stores.<\/jats:p>","DOI":"10.1523\/jneurosci.0675-06.2006","type":"journal-article","created":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T20:59:33Z","timestamp":1148504373000},"page":"5656-5664","source":"Crossref","is-referenced-by-count":105,"title":["Ca<sup>2+<\/sup>Influx through Mechanosensitive Channels Inhibits Neurite Outgrowth in Opposition to Other Influx Pathways and Release from Intracellular Stores"],"prefix":"10.1523","volume":"26","author":[{"given":"Bridget 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