{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:27:54Z","timestamp":1783711674753,"version":"3.55.0"},"reference-count":49,"publisher":"Society for Neuroscience","issue":"21","license":[{"start":{"date-parts":[[2010,11,26]],"date-time":"2010-11-26T00:00:00Z","timestamp":1290729600000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2010,5,26]]},"abstract":"<jats:p>The transcriptional coactivator peroxisome proliferator-activated receptor \u03b3 coactivator 1\u03b1 (PGC-1\u03b1) is a master regulator of metabolism in peripheral tissues, and it has been proposed that PGC-1\u03b1 plays a similar role in the brain. Recent evidence suggests that PGC-1\u03b1 is concentrated in GABAergic interneurons, so we investigated whether male and female PGC-1\u03b1 \u2212\/\u2212 mice exhibit abnormalities in interneuron gene expression and\/or function. We found a striking reduction in the expression of the Ca<jats:sup>2+<\/jats:sup>-binding protein parvalbumin (PV), but not other GABAergic markers, throughout the cerebrum in PGC-1\u03b1 +\/\u2212 and \u2212\/\u2212 mice. Furthermore, PGC-1\u03b1 overexpression in cell culture was sufficient to robustly induce PV expression. Consistent with a reduction in PV rather than a loss of PV-expressing interneurons, spontaneous synaptic inhibition was not altered in PGC-1\u03b1 \u2212\/\u2212 mice. However, evoked synaptic responses displayed less paired-pulse depression and dramatic facilitation in response to repetitive stimulation at the gamma frequency. PV transcript expression was also significantly reduced in retina and heart of PGC-1\u03b1 \u2212\/\u2212 animals, suggesting that PGC-1\u03b1 is required for proper expression of PV in multiple tissues. Together these findings indicate that PGC-1\u03b1 is a novel regulator of interneuron gene expression and function and a potential therapeutic target for neurological disorders associated with interneuron dysfunction.<\/jats:p>","DOI":"10.1523\/jneurosci.0698-10.2010","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T17:34:07Z","timestamp":1274895247000},"page":"7227-7235","source":"Crossref","is-referenced-by-count":102,"title":["Parvalbumin Deficiency and GABAergic Dysfunction in Mice Lacking PGC-1\u03b1"],"prefix":"10.1523","volume":"30","author":[{"given":"Elizabeth K.","family":"Lucas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J.","family":"Markwardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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