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Here, we show that<jats:italic>Drosophila<\/jats:italic>Nlg4 (DNlg4) is highly expressed in large ventral lateral clock neurons (l-LNvs) and that l-LNv-derived DNlg4 is essential for sleep regulation. GABA transmission is impaired in mutant l-LNv, and sleep defects in<jats:italic>dnlg4<\/jats:italic>mutant flies can be rescued by genetic manipulation of GABA transmission. Furthermore,<jats:italic>dnlg4<\/jats:italic>mutant flies exhibit a severe reduction in GABA<jats:sub>A<\/jats:sub>receptor RDL clustering, and DNlg4 associates with RDLs in<jats:italic>vivo<\/jats:italic>. These results demonstrate that DNlg4 regulates sleep through modulating GABA transmission in l-LNvs, which provides the first known link between a synaptic adhesion molecule and sleep in<jats:italic>Drosophila.<\/jats:italic><\/jats:p>","DOI":"10.1523\/jneurosci.0819-13.2013","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T16:47:08Z","timestamp":1380127628000},"page":"15545-15554","source":"Crossref","is-referenced-by-count":74,"title":["<i>Drosophila<\/i>Neuroligin 4 Regulates Sleep through Modulating GABA 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