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Based on embryological development, the \u201cone-map\u201d hypothesis proposes that the basic units of each map align in the adult animal and the aim of the present study was to test this possibility. In barbiturate anesthetized adult rats, nanoinjections of bidirectional tracer (Retrobeads and biotinylated dextran amine) were made into somatotopically identified regions within the hindlimb C1 zone in copula pyramidis. Injection sites were mapped relative to PC bands defined by the molecular marker zebrin II and were correlated with the pattern of retrograde cell labeling within the inferior olive and in the basilar pontine nuclei to determine connectivity of microzones and patches, respectively, and also with the distributions of biotinylated dextran amine-labeled PC terminals in the cerebellar nuclei. Zebrin bands were found to be related to both climbing fiber and mossy fiber inputs and also to cortical representation of different parts of the ipsilateral hindpaw, indicating a precise spatial organization within cerebellar microcircuitry. This precise connectivity extends to PC terminal fields in the cerebellar nuclei and olivonuclear projections. These findings strongly support the one-map hypothesis and suggest that, at the microcircuit level of resolution, the cerebellar cortex has a common plan of spatial organization for major inputs, outputs, and PC phenotype.<\/jats:p>","DOI":"10.1523\/jneurosci.0861-13.2013","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T15:07:34Z","timestamp":1381936054000},"page":"16427-16442","source":"Crossref","is-referenced-by-count":56,"title":["Structural Basis of Cerebellar Microcircuits in the Rat"],"prefix":"10.1523","volume":"33","author":[{"given":"Nadia L.","family":"Cerminara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanako","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Loft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Apps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2013,10,16]]},"reference":[{"key":"2023041304072466000_33.42.16427.1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903020205"},{"key":"2023041304072466000_33.42.16427.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1646"},{"key":"2023041304072466000_33.42.16427.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2698"},{"key":"2023041304072466000_33.42.16427.4","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-78-5-551"},{"key":"2023041304072466000_33.42.16427.5","doi-asserted-by":"crossref","unstructured":"Armstrong DM Campbell NC Edgley SA (1982) in The cerebellum\u2013new vistas, Investigations of the olivo-cerebellar and spino-olivary pathways, eds Palay SL Chan-Palay V (Springer, Berlin), pp 195\u2013232.","DOI":"10.1007\/978-3-642-68560-6_11"},{"key":"2023041304072466000_33.42.16427.6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971215)389:2<249::AID-CNE5>3.0.CO;2-1"},{"key":"2023041304072466000_33.42.16427.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.07.030"},{"key":"2023041304072466000_33.42.16427.8","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901850408"},{"key":"2023041304072466000_33.42.16427.9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1152\/jn.1983.49.3.745","article-title":"Congruence of spatial organization of tactile projections to granule cell and Purkinje cell layers of cerebellar hemispheres of the albino rat: vertical organization of cerebellar cortex","volume":"49","author":"Bower","year":"1983","journal-title":"J Neurophysiol"},{"key":"2023041304072466000_33.42.16427.10","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902910405"},{"key":"2023041304072466000_33.42.16427.11","unstructured":"Brodal P (1987) in New concepts in cerebellar neurobiology, Organization of cerebropontocerebellar connections as studied with anterograde and retrograde transport of HRP-WGA in the rat, ed King JS (Alan R. 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