{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:28:15Z","timestamp":1790940495587,"version":"4.1.0"},"reference-count":25,"publisher":"Society for Neuroscience","issue":"43","license":[{"start":{"date-parts":[[2012,4,26]],"date-time":"2012-04-26T00:00:00Z","timestamp":1335398400000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2011,10,26]]},"abstract":"<jats:p>Neuropathic pain is the most difficult type of pain to control, and patients lose their motivation for the purposive pursuit with a decrease in their quality of life. Using a functional magnetic resonance imaging analysis, we demonstrated that blood oxygenation level-dependent signal intensity was increased in the ipsilateral nucleus accumbens (N.Acc.) following peripheral nerve injury. microRNAs are small, noncoding RNA molecules that direct the post-transcriptional suppression of gene expression, and play an important role in regulating synaptic plasticity. In this study, we found that sciatic nerve ligation induced a drastic decrease in the expression of miR200b and miR429 in N.Acc. neurons. The expression of DNA methyltransferase 3a (DNMT3a), which is the one of the predicted targets of miR200b\/429, was significantly increased in the limbic forebrain including N.Acc. at 7 d after sciatic nerve ligation. Double-immunolabeling with antibodies specific to DNMT3a and NR1 showed that DNMT3a-immunoreactivity in the N.Acc. was located in NR1-labeled neurons, indicating that increased DNMT3a proteins were dominantly expressed in postsynaptic neurons in the N.Acc. area under a neuropathic pain-like state. The results of these analyses provide new insight into an epigenetic modification that is accompanied by a dramatic decrease in miR200b and miR429 along with the dysfunction of \u201cmesolimbic motivation\/valuation circuitry\u201d under a neuropathic pain-like state. These phenomena may result in an increase in DNMT3a in neurons of the N.Acc. under neuropathic pain, which leads to the long-term transcription-silencing of several genes.<\/jats:p>","DOI":"10.1523\/jneurosci.0921-11.2011","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T17:05:00Z","timestamp":1319648700000},"page":"15294-15299","source":"Crossref","is-referenced-by-count":91,"title":["Change in MicroRNAs Associated with Neuronal Adaptive Responses in the Nucleus Accumbens under Neuropathic Pain"],"prefix":"10.1523","volume":"31","author":[{"given":"Satoshi","family":"Imai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yanase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Kuzumaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2011,10,26]]},"reference":[{"key":"2023041303531509000_31.43.15294.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.07.004"},{"key":"2023041303531509000_31.43.15294.2","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"2023041303531509000_31.43.15294.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.03.002"},{"key":"2023041303531509000_31.43.15294.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.06.075"},{"key":"2023041303531509000_31.43.15294.5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4119-05.2005"},{"key":"2023041303531509000_31.43.15294.6","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2514"},{"key":"2023041303531509000_31.43.15294.7","unstructured":"Franklin KBJ Paxinos G (1997) The mouse brain in stereotaxic coordinates (Academic, San Diego), Ed 1."},{"key":"2023041303531509000_31.43.15294.8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020363"},{"key":"2023041303531509000_31.43.15294.9","doi-asserted-by":"publisher","DOI":"10.1038\/nn2010"},{"key":"2023041303531509000_31.43.15294.10","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2619"},{"key":"2023041303531509000_31.43.15294.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00045-1"},{"key":"2023041303531509000_31.43.15294.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.02.022"},{"key":"2023041303531509000_31.43.15294.13","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1523\/JNEUROSCI.21-11-03715.2001","article-title":"Involvement of spinal protein kinase Cgamma in the attenuation of opioid mu-receptor-mediated G-protein activation after chronic intrathecal administration of [D-Ala2,N-MePhe4,Gly-Ol(5)]enkephalin","volume":"21","author":"Narita","year":"2001","journal-title":"J Neurosci"},{"key":"2023041303531509000_31.43.15294.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03824.x"},{"key":"2023041303531509000_31.43.15294.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2010.00249.x"},{"key":"2023041303531509000_31.43.15294.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.02.016"},{"key":"2023041303531509000_31.43.15294.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.04.003"},{"key":"2023041303531509000_31.43.15294.18","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn011"},{"key":"2023041303531509000_31.43.15294.19","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1769"},{"key":"2023041303531509000_31.43.15294.20","doi-asserted-by":"publisher","DOI":"10.1038\/nature04367"},{"key":"2023041303531509000_31.43.15294.21","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-009-8065-2"},{"key":"2023041303531509000_31.43.15294.22","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/1.6.397"},{"key":"2023041303531509000_31.43.15294.23","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2132"},{"key":"2023041303531509000_31.43.15294.24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2637013100"},{"key":"2023041303531509000_31.43.15294.25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803072105"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.0921-11.2011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T20:44:25Z","timestamp":1681418665000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.0921-11.2011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,26]]},"references-count":25,"journal-issue":{"issue":"43","published-online":{"date-parts":[[2011,10,26]]},"published-print":{"date-parts":[[2011,10,26]]}},"alternative-id":["10.1523\/JNEUROSCI.0921-11.2011"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.0921-11.2011","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,26]]}}}