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Neurosci."],"published-print":{"date-parts":[[2022,12,14]]},"abstract":"<jats:p>Until recently, most modern neuroscience research on addiction using animal models did not incorporate manipulations of social factors. Social factors play a critical role in human addiction: social isolation and exclusion can promote drug use and relapse, while social connections and inclusion tend to be protective. Here, we discuss the state of the literature on social factors in animal models of opioid and psychostimulant preference, self-administration, and relapse. We first summarize results from rodent studies on behavioral, pharmacological, and circuit mechanisms of the protective effect of traditional experimenter-controlled social interaction procedures on opioid and psychostimulant conditioned place preference, self-administration, and relapse. Next, we summarize behavioral and brain-mechanism results from studies using newer operant social-interaction procedures that inhibit opioid and psychostimulant self-administration and relapse. We conclude by discussing how the reviewed studies point to future directions for the addiction field and other neuroscience and psychiatric fields, and their implications for mechanistic understanding of addiction and development of new treatments.<\/jats:p><jats:p><jats:bold>SIGNIFICANCE STATEMENT<\/jats:bold>In this review, we propose that incorporating social factors into modern neuroscience research on addiction could improve mechanistic accounts of addiction and help close gaps in translating discovery to treatment. We first summarize rodent studies on behavioral, pharmacological, and circuit mechanisms of the protective effect of both traditional experimenter-controlled and newer operant social-interaction procedures. We then discuss potential future directions and clinical implications.<\/jats:p>","DOI":"10.1523\/jneurosci.0931-22.2022","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T16:55:48Z","timestamp":1672851348000},"page":"9298-9314","source":"Crossref","is-referenced-by-count":39,"title":["The Protective Effect of Social Reward on Opioid and Psychostimulant Reward and Relapse: Behavior, Pharmacology, and Brain Regions"],"prefix":"10.1523","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-957X","authenticated-orcid":false,"given":"Marco","family":"Venniro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa A.M.","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Caprioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Ramsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavin","family":"Shaham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"2023041803550643000_42.50.9298.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5387.298"},{"key":"2023041803550643000_42.50.9298.2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.92.2.367"},{"key":"2023041803550643000_42.50.9298.3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00426903"},{"key":"2023041803550643000_42.50.9298.4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0296-18.2018"},{"key":"2023041803550643000_42.50.9298.5","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(95)00049-4"},{"key":"2023041803550643000_42.50.9298.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3362-8"},{"key":"2023041803550643000_42.50.9298.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-06048-7"},{"key":"2023041803550643000_42.50.9298.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.11.002"},{"key":"2023041803550643000_42.50.9298.9","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000569"},{"key":"2023041803550643000_42.50.9298.10","doi-asserted-by":"publisher","DOI":"10.1124\/pr.111.005124"},{"key":"2023041803550643000_42.50.9298.11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0937-16.2016"},{"key":"2023041803550643000_42.50.9298.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.09.023"},{"key":"2023041803550643000_42.50.9298.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.10.024"},{"key":"2023041803550643000_42.50.9298.14","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1846"},{"key":"2023041803550643000_42.50.9298.15","doi-asserted-by":"publisher","DOI":"10.1016\/0272-7358(91)90091-8"},{"key":"2023041803550643000_42.50.9298.16","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2017.00225"},{"key":"2023041803550643000_42.50.9298.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.018"},{"key":"2023041803550643000_42.50.9298.18","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0786-9"},{"key":"2023041803550643000_42.50.9298.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.018"},{"key":"2023041803550643000_42.50.9298.20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3091-16.2016"},{"key":"2023041803550643000_42.50.9298.21","unstructured":"Catania CA (1992) Learning. 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