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Epidemiological studies have long demonstrated a relationship between developmental cannabis exposure and later mental health symptoms. This relationship is especially strong in people with particular genetic polymorphisms, suggesting that cannabis use interacts with genotype to increase mental health risk. Seminal animal research directly linked prenatal and adolescent exposure to delta-9-tetrahydrocannabinol, the major psychoactive component of cannabis, with protracted effects on adult neural systems relevant to psychiatric and substance use disorders. In this article, we discuss some recent advances in understanding the long-term molecular, epigenetic, electrophysiological, and behavioral consequences of prenatal, perinatal, and adolescent exposure to cannabis\/delta-9-tetrahydrocannabinol. Insights are provided from both animal and human studies, including\n                    <jats:italic>in vivo<\/jats:italic>\n                    neuroimaging strategies.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.1165-19.2019","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T17:59:17Z","timestamp":1571248757000},"page":"8250-8258","source":"Crossref","is-referenced-by-count":205,"title":["Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects"],"prefix":"10.1523","volume":"39","author":[{"given":"Yasmin L.","family":"Hurd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5579-6208","authenticated-orcid":false,"given":"Olivier J.","family":"Manzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail 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