{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:53:39Z","timestamp":1792644819271,"version":"4.5.0"},"reference-count":86,"publisher":"Society for Neuroscience","issue":"39","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2014,9,24]]},"abstract":"<jats:p>After nerve injury, adult sensory neurons can regenerate peripheral axons and reconnect with their target tissue. Initiation of outgrowth, as well as elongation of neurites over long distances, depends on the signaling of receptors for neurotrophic growth factors. Here, we investigated the importance of gp130, the signaling subunit of neuropoietic cytokine receptors in peripheral nerve regeneration.<\/jats:p><jats:p>After sciatic nerve crush, functional recovery<jats:italic>in vivo<\/jats:italic>was retarded in<jats:italic>SNS-gp130<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>mice, which specifically lack<jats:italic>gp130<\/jats:italic>in sensory neurons. Correspondingly, a significantly reduced number of free nerve endings was detected in glabrous skin from<jats:italic>SNS-gp130<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>compared with control mice after nerve crush. Neurite outgrowth and STAT3 activation<jats:italic>in vitro<\/jats:italic>were severely reduced in cultures in gp130-deficient cultured neurons. Surprisingly, in neurons obtained from<jats:italic>SNS-gp130<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>mice the increase in neurite length was reduced not only in response to neuropoietic cytokine ligands of gp130 but also to nerve growth factor (NGF), which does not bind to gp130-containing receptors. Neurite outgrowth in the absence of neurotrophic factors was partially rescued in gp130-deficient neurons by leptin, which activates STAT3 downstream of leptic receptor and independent of gp130. The neurite outgrowth response of gp130-deficient neurons to NGF was fully restored in the presence of leptin.<\/jats:p><jats:p>Based on these findings, gp130 signaling via STAT3 activation is suggested not only to be an important regulator of peripheral nerve regeneration<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>, but as determining factor for the growth promoting action of NGF in adult sensory neurons.<\/jats:p>","DOI":"10.1523\/jneurosci.1209-13.2014","type":"journal-article","created":{"date-parts":[[2014,9,24]],"date-time":"2014-09-24T16:58:27Z","timestamp":1411577907000},"page":"13222-13233","source":"Crossref","is-referenced-by-count":62,"title":["Peripheral Nerve Regeneration and NGF-Dependent Neurite Outgrowth of Adult Sensory Neurons Converge on STAT3 Phosphorylation Downstream of Neuropoietic Cytokine Receptor gp130"],"prefix":"10.1523","volume":"34","author":[{"given":"Serena","family":"Quarta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian E.","family":"Baeumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Scherbakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Andratsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rose-John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Dechant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Bandtlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Kress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2014,9,24]]},"reference":[{"key":"2023041304131512000_34.39.13222.1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1916"},{"key":"2023041304131512000_34.39.13222.2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20010"},{"key":"2023041304131512000_34.39.13222.3","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1822-09.2009"},{"key":"2023041304131512000_34.39.13222.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.01.008"},{"key":"2023041304131512000_34.39.13222.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2009.08.012"},{"key":"2023041304131512000_34.39.13222.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015239108"},{"key":"2023041304131512000_34.39.13222.7","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.494"},{"key":"2023041304131512000_34.39.13222.8","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.10.1955"},{"key":"2023041304131512000_34.39.13222.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-012-1389-5"},{"key":"2023041304131512000_34.39.13222.10","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1093"},{"key":"2023041304131512000_34.39.13222.11","doi-asserted-by":"crossref","first-page":"7161","DOI":"10.1523\/JNEUROSCI.21-18-07161.2001","article-title":"Leukemia inhibitory factor determines the growth status of injured adult sensory neurons","volume":"21","author":"Cafferty","year":"2001","journal-title":"J Neurosci"},{"key":"2023041304131512000_34.39.13222.12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2245-02.2004"},{"key":"2023041304131512000_34.39.13222.13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0815-06.2006"},{"key":"2023041304131512000_34.39.13222.14","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"2023041304131512000_34.39.13222.15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00227180","article-title":"Influence of leukemia inhibitory factor on galanin\/GMAP and neuropeptide Y expression in mouse primary sensory neurons after axotomy","volume":"112","author":"Corness","year":"1996","journal-title":"Exp Brain Res"},{"key":"2023041304131512000_34.39.13222.16","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(86)90109-7"},{"key":"2023041304131512000_34.39.13222.17","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"2023041304131512000_34.39.13222.18","doi-asserted-by":"publisher","DOI":"10.1159\/000088015"},{"key":"2023041304131512000_34.39.13222.19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.19.030196.002013"},{"key":"2023041304131512000_34.39.13222.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2003.11.003"},{"key":"2023041304131512000_34.39.13222.21","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0297-142"},{"key":"2023041304131512000_34.39.13222.22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01101.x"},{"key":"2023041304131512000_34.39.13222.23","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-110"},{"key":"2023041304131512000_34.39.13222.24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05155.x"},{"key":"2023041304131512000_34.39.13222.25","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20706"},{"key":"2023041304131512000_34.39.13222.26","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90026-7"},{"key":"2023041304131512000_34.39.13222.27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/bj3340297","article-title":"Interleukin-6-type cytokine signalling through the gp130\/Jak\/STAT pathway","volume":"334","author":"Heinrich","year":"1998","journal-title":"Biochem J"},{"key":"2023041304131512000_34.39.13222.28","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20030407"},{"key":"2023041304131512000_34.39.13222.29","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90411-7"},{"key":"2023041304131512000_34.39.13222.30","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2627"},{"key":"2023041304131512000_34.39.13222.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.01.019"},{"key":"2023041304131512000_34.39.13222.32","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57158"},{"key":"2023041304131512000_34.39.13222.33","doi-asserted-by":"publisher","DOI":"10.1126\/science.1850549"},{"key":"2023041304131512000_34.39.13222.34","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1002\/j.1460-2075.1989.tb08545.x","article-title":"trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development","volume":"8","author":"Klein","year":"1989","journal-title":"EMBO J"},{"key":"2023041304131512000_34.39.13222.35","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90628-C"},{"key":"2023041304131512000_34.39.13222.36","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90209-V"},{"key":"2023041304131512000_34.39.13222.37","doi-asserted-by":"publisher","DOI":"10.1038\/368339a0"},{"key":"2023041304131512000_34.39.13222.38","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90442-2"},{"key":"2023041304131512000_34.39.13222.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.01.014"},{"key":"2023041304131512000_34.39.13222.40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1952.tb26548.x"},{"key":"2023041304131512000_34.39.13222.41","doi-asserted-by":"publisher","DOI":"10.1126\/science.3306916"},{"key":"2023041304131512000_34.39.13222.42","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4065-05.2006"},{"key":"2023041304131512000_34.39.13222.43","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1523\/JNEUROSCI.08-07-02394.1988","article-title":"Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons","volume":"8","author":"Lindsay","year":"1988","journal-title":"J Neurosci"},{"key":"2023041304131512000_34.39.13222.44","doi-asserted-by":"crossref","first-page":"RC164","DOI":"10.1523\/JNEUROSCI.21-17-j0003.2001","article-title":"Different signaling pathways mediate regenerative versus developmental sensory axon growth","volume":"21","author":"Liu","year":"2001","journal-title":"J Neurosci"},{"key":"2023041304131512000_34.39.13222.45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01705.x"},{"key":"2023041304131512000_34.39.13222.46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3251"},{"key":"2023041304131512000_34.39.13222.47","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20022"},{"key":"2023041304131512000_34.39.13222.48","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3947-10.2010"},{"key":"2023041304131512000_34.39.13222.49","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000952"},{"key":"2023041304131512000_34.39.13222.50","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1523\/JNEUROSCI.15-07-05130.1995","article-title":"Induction of interleukin-6 in axotomized sensory neurons","volume":"15","author":"Murphy","year":"1995","journal-title":"J Neurosci"},{"key":"2023041304131512000_34.39.13222.51","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00641.x"},{"key":"2023041304131512000_34.39.13222.52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304623200"},{"key":"2023041304131512000_34.39.13222.53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601863200"},{"key":"2023041304131512000_34.39.13222.54","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0101com"},{"key":"2023041304131512000_34.39.13222.55","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00420-1"},{"key":"2023041304131512000_34.39.13222.56","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh490"},{"key":"2023041304131512000_34.39.13222.57","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4280"},{"key":"2023041304131512000_34.39.13222.58","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3269-04.2005"},{"key":"2023041304131512000_34.39.13222.59","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-73"},{"key":"2023041304131512000_34.39.13222.60","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00611-8"},{"key":"2023041304131512000_34.39.13222.61","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1242\/dev.116.3.731","article-title":"Multiple cholinergic differentiation factors are present in footpad extracts: comparison with known cholinergic factors","volume":"116","author":"Rao","year":"1992","journal-title":"Development"},{"key":"2023041304131512000_34.39.13222.62","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.108.5.1807"},{"key":"2023041304131512000_34.39.13222.63","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0484-x"},{"key":"2023041304131512000_34.39.13222.64","doi-asserted-by":"publisher","DOI":"10.1089\/107999099313974"},{"key":"2023041304131512000_34.39.13222.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2006.09.018"},{"key":"2023041304131512000_34.39.13222.66","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00005.x"},{"key":"2023041304131512000_34.39.13222.67","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201203109"},{"key":"2023041304131512000_34.39.13222.68","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.1523\/JNEUROSCI.17-18-06999.1997","article-title":"Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice","volume":"17","author":"Sendtner","year":"1997","journal-title":"J Neurosci"},{"key":"2023041304131512000_34.39.13222.69","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200104170-00043"},{"key":"2023041304131512000_34.39.13222.70","doi-asserted-by":"publisher","DOI":"10.2174\/187152708783885174"},{"key":"2023041304131512000_34.39.13222.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.10.004"},{"key":"2023041304131512000_34.39.13222.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2010.07.015"},{"key":"2023041304131512000_34.39.13222.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2011.01.002"},{"key":"2023041304131512000_34.39.13222.74","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02189"},{"key":"2023041304131512000_34.39.13222.75","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1046\/j.1471-4159.1996.67041751.x","article-title":"Involvement of leukemia inhibitory factor in the increases in galanin and vasoactive intestinal peptide mRNA and the decreases in neuropeptide Y and tyrosine hydroxylase mRNA in sympathetic neurons after axotomy","volume":"67","author":"Sun","year":"1996","journal-title":"J Neurochem"},{"key":"2023041304131512000_34.39.13222.76","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2011.00060"},{"key":"2023041304131512000_34.39.13222.77","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.1999.19410001.x"},{"key":"2023041304131512000_34.39.13222.78","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(02)00106-3"},{"key":"2023041304131512000_34.39.13222.79","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.08.002"},{"key":"2023041304131512000_34.39.13222.80","doi-asserted-by":"publisher","DOI":"10.2174\/138161207780858429"},{"key":"2023041304131512000_34.39.13222.81","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81114-9"},{"key":"2023041304131512000_34.39.13222.82","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1523\/JNEUROSCI.19-11-04305.1999","article-title":"Sensory impairments and delayed regeneration of sensory axons in interleukin-6-deficient mice","volume":"19","author":"Zhong","year":"1999","journal-title":"J Neurosci"},{"key":"2023041304131512000_34.39.13222.83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021680"},{"key":"2023041304131512000_34.39.13222.84","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2011.00062"},{"key":"2023041304131512000_34.39.13222.85","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"},{"key":"2023041304131512000_34.39.13222.86","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.015"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.1209-13.2014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T22:13:35Z","timestamp":1681424015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.1209-13.2014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,24]]},"references-count":86,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2014,9,24]]},"published-print":{"date-parts":[[2014,9,24]]}},"alternative-id":["10.1523\/JNEUROSCI.1209-13.2014"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.1209-13.2014","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,24]]}}}