{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:19:52Z","timestamp":1773958792082,"version":"3.50.1"},"reference-count":59,"publisher":"Society for Neuroscience","issue":"34","license":[{"start":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T00:00:00Z","timestamp":1172188800000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,8,23]]},"abstract":"<jats:p>Conus medullaris and\/or cauda equina forms of spinal cord injury commonly result in a permanent loss of bladder function. Here, we developed a cauda equina injury and repair rodent model to investigate whether surgical implantation of avulsed lumbosacral ventral roots into the spinal cord can promote functional recovery of the lower urinary tract. Adult female rats underwent sham surgery (<jats:italic>n<\/jats:italic>= 6), bilateral L5\u2013S2 ventral root avulsion (VRA) injury (<jats:italic>n<\/jats:italic>= 5), or bilateral L5\u2013S2 VRA followed by an acute implantation of the avulsed L6 and S1 ventral roots into the conus medullaris (<jats:italic>n<\/jats:italic>= 6). At 12 weeks after operation, the avulsed group demonstrated urinary retention, absence of bladder contractions and external urethral sphincter (EUS) electromyographic (EMG) activation during urodynamic recordings, increased bladder size, and retrograde death of autonomic and motoneurons in the spinal cord. In contrast, the implanted group showed reduced urinary retention, return of reflexive bladder voiding contractions coincident with EUS EMG activation, anatomical reinnervation of the EUS demonstrated by retrograde neuronal labeling, normalization of bladder size, and a significant neuroprotection of both autonomic and motoneurons. In addition, a positive correlation between motoneuronal survival and voiding efficiency was observed in the implanted group. Our results show that implantation of avulsed lumbosacral ventral roots into the spinal cord promotes reinnervation of the urinary tract and return of functional micturition reflexes, suggesting that this surgical repair strategy may also be of clinical interest after conus medullaris and cauda equina injuries.<\/jats:p>","DOI":"10.1523\/jneurosci.1259-06.2006","type":"journal-article","created":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T16:53:05Z","timestamp":1156351985000},"page":"8672-8679","source":"Crossref","is-referenced-by-count":42,"title":["Functional Reinnervation of the Rat Lower Urinary Tract after Cauda Equina Injury and Repair"],"prefix":"10.1523","volume":"26","author":[{"given":"Thao X.","family":"Hoang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Pikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif A.","family":"Havton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2006,8,23]]},"reference":[{"key":"2023041303200765000_26.34.8672.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.09.010"},{"key":"2023041303200765000_26.34.8672.2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2004.21.1371"},{"key":"2023041303200765000_26.34.8672.3","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902290305"},{"key":"2023041303200765000_26.34.8672.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.02.003"},{"key":"2023041303200765000_26.34.8672.5","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/S0022-5347(17)37047-7","article-title":"Function of the conus medullaris and cauda equina in the early period following spinal cord injury and the relationship to recovery of detrusor function","volume":"148","author":"Beric","year":"1992","journal-title":"J Urol"},{"key":"2023041303200765000_26.34.8672.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.05.014"},{"key":"2023041303200765000_26.34.8672.7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3109\/00365596809135368","article-title":"Reconstruction of severed ventral roots innervating the urinary bladder. 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