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We report that transiently decreased amygdala Mecp2 expression during a sensitive period of brain sexual differentiation disrupts the organization of sex differences in juvenile social play behavior. Interestingly, neonatal treatment with Mecp2 small interfering RNA within the developing amygdala reduced juvenile social play behavior in males but not females. Reduced Mecp2 expression did not change juvenile sociability or anxiety-like behavior, suggesting that this disruption is associated with subtle behavioral modification. This suggests that Mecp2 may have an overlooked role in the organization of sexually dimorphic behaviors and that male juvenile behavior is particularly sensitive to Mecp2 disruption during this period of development.<\/jats:p>","DOI":"10.1523\/jneurosci.1345-08.2008","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T16:23:14Z","timestamp":1215620594000},"page":"7137-7142","source":"Crossref","is-referenced-by-count":85,"title":["Mecp2 Organizes Juvenile Social Behavior in a Sex-Specific Manner"],"prefix":"10.1523","volume":"28","author":[{"given":"Joseph R.","family":"Kurian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meaghan E.","family":"Bychowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin 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