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Unitary IPSCs (uIPSCs) evoked by action potentials of FS-GABA neurons have shorter onset latency, faster rising slope, higher peak amplitude, and faster decay time than those evoked by action potentials of non-FS-GABA neurons. Tetanic activation of presynaptic FS-GABA neurons induced long-term potentiation (LTP) of uIPSCs, whereas that of presynaptic non-FS-GABA neurons did not induce LTP, indicating that long-term plasticity of inhibitory synapses on FS-GABA neurons is pathway specific. For further analysis of inhibitory synaptic plasticity, IPSPs evoked by electrical stimulation of an adjacent site in the cortex were recorded from FS-GABA neurons. Theta burst stimulation induced LTP of IPSPs in 12 of 14 FS-GABA neurons. The paired-pulse stimulation protocol and coefficient of variation analysis indicated that this form of LTP may be presynaptic in origin. Filling postsynaptic cells with a Ca<jats:sup>2+<\/jats:sup>chelator did not block the induction of LTP, suggesting no involvement of postsynaptic Ca<jats:sup>2+<\/jats:sup>rise. Also, this form of LTP was dependent neither on metabotropic glutamate receptors nor voltage-gated Ca<jats:sup>2+<\/jats:sup>channels of the L and T types. Further pharmacological analysis indicated that voltage-gated Ca<jats:sup>2+<\/jats:sup>channels other than the P\/Q type, such as N and R types, were not involved in LTP, suggesting that P\/Q-type channels are a candidate for factors inducing LTP of inhibitory synapses between FS-GABA neurons.<\/jats:p>","DOI":"10.1523\/jneurosci.1386-12.2012","type":"journal-article","created":{"date-parts":[[2012,9,19]],"date-time":"2012-09-19T16:33:16Z","timestamp":1348072396000},"page":"13189-13199","source":"Crossref","is-referenced-by-count":28,"title":["Cell Type-Specific, Presynaptic LTP of Inhibitory Synapses on Fast-Spiking GABAergic Neurons in the Mouse Visual 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