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Male mating is the most complex behavior exhibited by the nematode<jats:italic>C. elegans<\/jats:italic>and involves the steps of response, backing, turning, vulva location, spicule insertion, and sperm transfer. Because neuropeptides are important neural regulators of many complex animal behaviors, we explored the function of the FMRFamide-like neuropeptide (<jats:italic>flp<\/jats:italic>) gene family in regulating male copulation. We found that peptidergic signaling mediated by FMRF-amide like neuropeptides (FLPs) FLP-8, FLP-10, FLP-12, and FLP-20 is required for the sensory transduction involved in male turning behavior.<jats:italic>flp-8<\/jats:italic>,<jats:italic>flp-10<\/jats:italic>,<jats:italic>flp-12<\/jats:italic>, and<jats:italic>flp-20<\/jats:italic>mutant males significantly increase repetition of substep(s) of turning behavior compared with wild-type males. Genes controlling neuropeptide processing and secretion in general, including<jats:italic>egl-3<\/jats:italic>,<jats:italic>egl-21<\/jats:italic>,<jats:italic>ida-1<\/jats:italic>, and<jats:italic>unc-31<\/jats:italic>, are also required for inhibiting repetitive turning behavior. Neuropeptidergic signaling adjusts the repetitiveness of turning independently of serotonergic modulation of the timing of turning. Surprisingly, the mechanosensitive touch receptor neurons are found to be part of the neural circuitry regulating male turning behavior, indicating the existence of functional dimorphisms in the nervous system with regard to sex-specific behaviors.<\/jats:p>","DOI":"10.1523\/jneurosci.1405-07.2007","type":"journal-article","created":{"date-parts":[[2007,7,4]],"date-time":"2007-07-04T16:47:53Z","timestamp":1183567673000},"page":"7174-7182","source":"Crossref","is-referenced-by-count":71,"title":["FMRFamide-Like Neuropeptides and Mechanosensory Touch Receptor Neurons Regulate Male Sexual Turning Behavior in<i>Caenorhabditis elegans<\/i>"],"prefix":"10.1523","volume":"27","author":[{"given":"Tiewen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuhyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen M.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2007,7,4]]},"reference":[{"key":"2023041303261889000_27.27.7174.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.02.024"},{"key":"2023041303261889000_27.27.7174.2","doi-asserted-by":"publisher","DOI":"10.1038\/43916"},{"key":"2023041303261889000_27.27.7174.3","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6920-3-1"},{"key":"2023041303261889000_27.27.7174.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.01.016"},{"key":"2023041303261889000_27.27.7174.5","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/20031967725"},{"key":"2023041303261889000_27.27.7174.6","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1523\/JNEUROSCI.21-05-01510.2001","article-title":"Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42","volume":"21","author":"Brockie","year":"2001","journal-title":"J Neurosci"},{"key":"2023041303261889000_27.27.7174.7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3399-05.2005"},{"key":"2023041303261889000_27.27.7174.8","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90459-0"},{"key":"2023041303261889000_27.27.7174.9","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1523\/JNEUROSCI.05-04-00956.1985","article-title":"The neural circuit for touch sensitivity in Caenorhabditis elegans","volume":"5","author":"Chalfie","year":"1985","journal-title":"J Neurosci"},{"key":"2023041303261889000_27.27.7174.10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608050104"},{"key":"2023041303261889000_27.27.7174.11","doi-asserted-by":"publisher","DOI":"10.1038\/349588a0"},{"key":"2023041303261889000_27.27.7174.12","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1523\/JNEUROSCI.19-15-06225.1999","article-title":"Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein","volume":"19","author":"Eastman","year":"1999","journal-title":"J Neurosci"},{"key":"2023041303261889000_27.27.7174.13","unstructured":"Emmons SW Sternberg PW (1997) in C. elegans II, Male development and mating behavior, eds Riddle DL Blumenthal T Meyer BJ Priess JR (Cold Spring Harbor Laboratory, New York)."},{"key":"2023041303261889000_27.27.7174.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00600-6"},{"key":"2023041303261889000_27.27.7174.15","doi-asserted-by":"publisher","DOI":"10.1038\/4151039a"},{"key":"2023041303261889000_27.27.7174.16","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E05-02-0096"},{"key":"2023041303261889000_27.27.7174.17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3364-05.2006"},{"key":"2023041303261889000_27.27.7174.18","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1002\/j.1460-2075.1992.tb05357.x","article-title":"The mec-7 beta-tubulin gene of Caenorhabditis elegans is expressed primarily in the touch receptor neurons","volume":"11","author":"Hamelin","year":"1992","journal-title":"EMBO J"},{"key":"2023041303261889000_27.27.7174.19","doi-asserted-by":"crossref","unstructured":"Hill RG Oliver KR (2007) Neuropeptide and kinin antagonists. 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