{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:38:30Z","timestamp":1791268710530,"version":"4.1.0"},"reference-count":47,"publisher":"Society for Neuroscience","issue":"42","license":[{"start":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T00:00:00Z","timestamp":1334793600000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2011,10,19]]},"abstract":"<jats:p>Temporal correlations between different brain regions in the resting-state BOLD signal are thought to reflect intrinsic functional brain connectivity (Biswal et al., 1995; Greicius et al., 2003; Fox et al., 2007). The functional networks identified are typically bilaterally distributed across the cerebral hemispheres, show similarity to known white matter connections (Greicius et al., 2009), and are seen even in anesthetized monkeys (Vincent et al., 2007). Yet it remains unclear how they arise. Here we tested two distinct possibilities: (1) functional networks arise largely from structural connectivity constraints, and generally require direct interactions between functionally coupled regions mediated by white-matter tracts; and (2) functional networks emerge flexibly with the development of normal cognition and behavior and can be realized in multiple structural architectures. We conducted resting-state fMRI in eight adult humans with complete agenesis of the corpus callosum (AgCC) and normal intelligence, and compared their data to those from eight healthy matched controls. We performed three main analyses: anatomical region-of-interest-based correlations to test homotopic functional connectivity, independent component analysis (ICA) to reveal functional networks with a data-driven approach, and ICA-based interhemispheric correlation analysis. Both groups showed equivalently strong homotopic BOLD correlation. Surprisingly, almost all of the group-level independent components identified in controls were observed in AgCC and were predominantly bilaterally symmetric. The results argue that a normal complement of resting-state networks and intact functional coupling between the hemispheres can emerge in the absence of the corpus callosum, favoring the second over the first possibility listed above.<\/jats:p>","DOI":"10.1523\/jneurosci.1453-11.2011","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T21:18:14Z","timestamp":1319059094000},"page":"15154-15162","source":"Crossref","is-referenced-by-count":160,"title":["Intact Bilateral Resting-State Networks in the Absence of the Corpus Callosum"],"prefix":"10.1523","volume":"31","author":[{"given":"J. Michael","family":"Tyszka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Adolphs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn K.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2011,10,19]]},"reference":[{"key":"2023041303530639000_31.42.15154.1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq190"},{"key":"2023041303530639000_31.42.15154.2","unstructured":"Andersson JL Smith S Jenkinson M (2008) Paper presented at Meeting for the Organization for Human Brain Mapping (June, Melbourne, Australia), FNIRT: FMRIB non-linear image registration tool."},{"key":"2023041303530639000_31.42.15154.3","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2003.822821"},{"key":"2023041303530639000_31.42.15154.4","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"2023041303530639000_31.42.15154.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911855107"},{"key":"2023041303530639000_31.42.15154.6","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53884-0.00031-2"},{"key":"2023041303530639000_31.42.15154.7","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.1048"},{"key":"2023041303530639000_31.42.15154.8","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2466\/pms.1995.80.2.504","article-title":"EEG interhemispheric correlation after callosotomy: one case study","volume":"80","author":"Corsi-Cabrera","year":"1995","journal-title":"Percept Mot Skills"},{"key":"2023041303530639000_31.42.15154.9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601417103"},{"key":"2023041303530639000_31.42.15154.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"2023041303530639000_31.42.15154.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007921107"},{"key":"2023041303530639000_31.42.15154.12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000381"},{"key":"2023041303530639000_31.42.15154.13","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0396"},{"key":"2023041303530639000_31.42.15154.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.08.023"},{"key":"2023041303530639000_31.42.15154.15","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90777.2008"},{"key":"2023041303530639000_31.42.15154.16","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq071"},{"key":"2023041303530639000_31.42.15154.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.07.022"},{"key":"2023041303530639000_31.42.15154.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.08.012"},{"key":"2023041303530639000_31.42.15154.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"2023041303530639000_31.42.15154.20","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn059"},{"key":"2023041303530639000_31.42.15154.21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009073107"},{"key":"2023041303530639000_31.42.15154.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2009.04.004"},{"key":"2023041303530639000_31.42.15154.23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811168106"},{"key":"2023041303530639000_31.42.15154.24","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22818"},{"key":"2023041303530639000_31.42.15154.25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0573-08.2008"},{"key":"2023041303530639000_31.42.15154.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.10.052"},{"key":"2023041303530639000_31.42.15154.27","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp278"},{"key":"2023041303530639000_31.42.15154.28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5122-09.2010"},{"key":"2023041303530639000_31.42.15154.29","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1093\/cercor\/bhr019","article-title":"Direct comparison of spontaneous functional connectivity and effective connectivity measured by intracortical microstimulation: an fMRI study in macaque monkeys","volume":"10","author":"Matsui","year":"2011","journal-title":"Cereb Cortex"},{"key":"2023041303530639000_31.42.15154.30","unstructured":"Mazaika PK Whitfield S Cooper JC (2005) Paper presented at Meeting of the Society for Human Brain Mapping (June, Toronto, Ontario, Canada), Detection and Repair of Transient Artifacts in fMRI Data."},{"key":"2023041303530639000_31.42.15154.31","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"2023041303530639000_31.42.15154.32","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2107"},{"key":"2023041303530639000_31.42.15154.33","unstructured":"Paul LK Corsello C Kennedy DP Childress D Cheng BC Adolphs R (2011) Paper presented at International Meeting for Autism Research (May, San Diego, CA), Autism symptomatology in primary agenesis of the corpus callosum."},{"key":"2023041303530639000_31.42.15154.34","first-page":"208","article-title":"Role of the corpus callosum in functional connectivity","volume":"24","author":"Quigley","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"2023041303530639000_31.42.15154.35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"2023041303530639000_31.42.15154.36","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00003.2003"},{"key":"2023041303530639000_31.42.15154.37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"2023041303530639000_31.42.15154.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.07.008"},{"key":"2023041303530639000_31.42.15154.39","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj127"},{"key":"2023041303530639000_31.42.15154.40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4544-08.2008"},{"key":"2023041303530639000_31.42.15154.41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000157"},{"key":"2023041303530639000_31.42.15154.42","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn014"},{"key":"2023041303530639000_31.42.15154.43","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3282fb8203"},{"key":"2023041303530639000_31.42.15154.44","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1443-09.2009"},{"key":"2023041303530639000_31.42.15154.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.02.010"},{"key":"2023041303530639000_31.42.15154.46","doi-asserted-by":"publisher","DOI":"10.1038\/nature05758"},{"key":"2023041303530639000_31.42.15154.47","doi-asserted-by":"publisher","DOI":"10.1109\/42.906424"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.1453-11.2011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T20:44:35Z","timestamp":1681418675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.1453-11.2011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,19]]},"references-count":47,"journal-issue":{"issue":"42","published-online":{"date-parts":[[2011,10,19]]},"published-print":{"date-parts":[[2011,10,19]]}},"alternative-id":["10.1523\/JNEUROSCI.1453-11.2011"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.1453-11.2011","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,19]]}}}