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One week after birth, almost all (\u223c80%) ankle extensor motoneurons recorded in whole-cell configuration displayed self-sustained spiking in response to a brief depolarization that emerged when the temperature was raised &gt;30\u00b0C. The effect of L-type Ca<jats:sup>2+<\/jats:sup>channel blockers on self-sustained spiking was variable, whereas blockade of the persistent sodium current (I<jats:sub>NaP<\/jats:sub>) abolished them. When hyperpolarized, bistable motoneurons displayed a characteristic slow afterdepolarization (sADP). The sADPs generated by repeated depolarizing pulses summed to promote a plateau potential. The sADP was tightly associated with the emergence of Ca<jats:sup>2+<\/jats:sup>spikes. Substitution of extracellular Na<jats:sup>+<\/jats:sup>or chelation of intracellular Ca<jats:sup>2+<\/jats:sup>abolished both sADP and the plateau potential without affecting Ca<jats:sup>2+<\/jats:sup>spikes. These data suggest a key role of a Ca<jats:sup>2+<\/jats:sup>-activated nonselective cation conductance (I<jats:sub>CaN<\/jats:sub>) in generating the plateau potential. In line with this, the blockade of I<jats:sub>CaN<\/jats:sub>by flufenamate abolished both sADP and plateau potentials. Furthermore, 2-aminoethoxydiphenyl borate (2-APB), a common activator of thermo-sensitive vanilloid transient receptor potential (TRPV) cation channels, promoted the sADP. Among TRPV channels, only the selective activation of TRPV2 channels by probenecid promoted the sADP to generate a plateau potential. To conclude, bistable behaviors are, to a large extent, determined by the interplay between three currents: L-type I<jats:sub>Ca<\/jats:sub>, I<jats:sub>NaP<\/jats:sub>, and a Na<jats:sup>+<\/jats:sup>-mediated I<jats:sub>CaN<\/jats:sub>flowing through putative TRPV2 channels.<\/jats:p>","DOI":"10.1523\/jneurosci.1483-13.2013","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T16:47:08Z","timestamp":1380127628000},"page":"15626-15641","source":"Crossref","is-referenced-by-count":63,"title":["Sodium-Mediated Plateau Potentials in Lumbar Motoneurons of Neonatal 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