{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:24:39Z","timestamp":1790763879593,"version":"4.1.0"},"reference-count":126,"publisher":"Society for Neuroscience","issue":"42","license":[{"start":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T00:00:00Z","timestamp":1429056000000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2014,10,15]]},"abstract":"<jats:p>The neuromuscular junction (NMJ) is a synapse between motor neurons and skeletal muscle fibers, and is critical for control of muscle contraction. Its formation requires neuronal agrin that acts by binding to LRP4 to stimulate MuSK. Mutations have been identified in<jats:italic>agrin<\/jats:italic>,<jats:italic>MuSK<\/jats:italic>, and<jats:italic>LRP4<\/jats:italic>in patients with congenital myasthenic syndrome, and patients with myasthenia gravis develop antibodies against agrin, LRP4, and MuSK. However, it remains unclear whether the agrin signaling pathway is critical for NMJ maintenance because null mutation of any of the three genes is perinatal lethal. In this study, we generated imKO mice, a mutant strain whose<jats:italic>LRP4<\/jats:italic>gene can be deleted in muscles by doxycycline (Dox) treatment. Ablation of the<jats:italic>LRP4<\/jats:italic>gene in adult muscle enabled studies of its role in NMJ maintenance. We demonstrate that Dox treatment of P30 mice reduced muscle strength and compound muscle action potentials. AChR clusters became fragmented with diminished junctional folds and synaptic vesicles. The amplitude and frequency of miniature endplate potentials were reduced, indicating impaired neuromuscular transmission and providing cellular mechanisms of adult LRP4 deficiency. We showed that LRP4 ablation led to the loss of synaptic agrin and the 90 kDa fragments, which occurred ahead of other prejunctional and postjunctional components, suggesting that LRP4 may regulate the stability of synaptic agrin. These observations demonstrate that LRP4 is essential for maintaining the structural and functional integrity of the NMJ and that loss of muscle LRP4 in adulthood alone is sufficient to cause myasthenic symptoms.<\/jats:p>","DOI":"10.1523\/jneurosci.1733-14.2014","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T17:14:20Z","timestamp":1413393260000},"page":"13892-13905","source":"Crossref","is-referenced-by-count":142,"title":["LRP4 Is Critical for Neuromuscular Junction Maintenance"],"prefix":"10.1523","volume":"34","author":[{"given":"Arnab","family":"Barik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-3043","authenticated-orcid":false,"given":"Anupama","family":"Sathyamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-cheng","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2014,10,15]]},"reference":[{"key":"2023041304133498000_34.42.13892.1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.085118"},{"key":"2023041304133498000_34.42.13892.2","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0834"},{"key":"2023041304133498000_34.42.13892.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.11.005"},{"key":"2023041304133498000_34.42.13892.4","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000020619.24681.2b"},{"key":"2023041304133498000_34.42.13892.5","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-824-5_11"},{"key":"2023041304133498000_34.42.13892.6","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22190"},{"key":"2023041304133498000_34.42.13892.7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1130837"},{"key":"2023041304133498000_34.42.13892.8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053826"},{"key":"2023041304133498000_34.42.13892.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1074"},{"key":"2023041304133498000_34.42.13892.10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171539698"},{"key":"2023041304133498000_34.42.13892.11","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(94)90034-5"},{"key":"2023041304133498000_34.42.13892.12","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr396"},{"key":"2023041304133498000_34.42.13892.13","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.072090"},{"key":"2023041304133498000_34.42.13892.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.01.014"},{"key":"2023041304133498000_34.42.13892.15","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90324-7"},{"key":"2023041304133498000_34.42.13892.16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1242\/dev.116.1.41","article-title":"Synapse-specific expression of acetylcholine receptor genes and their products at original synaptic sites in rat soleus muscle fibres regenerating in the absence of innervation","volume":"116","author":"Brenner","year":"1992","journal-title":"Development"},{"key":"2023041304133498000_34.42.13892.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.07.018"},{"key":"2023041304133498000_34.42.13892.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80751-5"},{"key":"2023041304133498000_34.42.13892.19","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.1.41"},{"key":"2023041304133498000_34.42.13892.20","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90051-5"},{"key":"2023041304133498000_34.42.13892.21","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn251"},{"key":"2023041304133498000_34.42.13892.22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007930"},{"key":"2023041304133498000_34.42.13892.23","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00220"},{"key":"2023041304133498000_34.42.13892.24","doi-asserted-by":"publisher","DOI":"10.1038\/15519"},{"key":"2023041304133498000_34.42.13892.25","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1523\/JNEUROSCI.18-13-04953.1998","article-title":"Axon withdrawal during synapse elimination at the neuromuscular junction is accompanied by disassembly of the postsynaptic specialization and withdrawal of Schwann cell processes","volume":"18","author":"Culican","year":"1998","journal-title":"J Neurosci"},{"key":"2023041304133498000_34.42.13892.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81251-9"},{"key":"2023041304133498000_34.42.13892.27","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.137.3.671"},{"key":"2023041304133498000_34.42.13892.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80034-3"},{"key":"2023041304133498000_34.42.13892.29","doi-asserted-by":"publisher","DOI":"10.1038\/345315a0"},{"key":"2023041304133498000_34.42.13892.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(03)00036-1"},{"key":"2023041304133498000_34.42.13892.31","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90135-X"},{"key":"2023041304133498000_34.42.13892.32","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.016"},{"key":"2023041304133498000_34.42.13892.33","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.69.1.144"},{"key":"2023041304133498000_34.42.13892.34","doi-asserted-by":"publisher","DOI":"10.1242\/dev.010702"},{"key":"2023041304133498000_34.42.13892.35","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.110841"},{"key":"2023041304133498000_34.42.13892.36","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81253-2"},{"key":"2023041304133498000_34.42.13892.37","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90052-3"},{"key":"2023041304133498000_34.42.13892.38","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.4.625"},{"key":"2023041304133498000_34.42.13892.39","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80096-3"},{"key":"2023041304133498000_34.42.13892.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81252-0"},{"key":"2023041304133498000_34.42.13892.41","doi-asserted-by":"publisher","DOI":"10.1242\/dev.071555"},{"key":"2023041304133498000_34.42.13892.42","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200209045"},{"key":"2023041304133498000_34.42.13892.43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708607200"},{"key":"2023041304133498000_34.42.13892.44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806300105"},{"key":"2023041304133498000_34.42.13892.45","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11661-F"},{"key":"2023041304133498000_34.42.13892.46","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.10.020"},{"key":"2023041304133498000_34.42.13892.47","doi-asserted-by":"publisher","DOI":"10.1038\/85520"},{"key":"2023041304133498000_34.42.13892.48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1313944110"},{"key":"2023041304133498000_34.42.13892.49","doi-asserted-by":"publisher","DOI":"10.1038\/355696a0"},{"key":"2023041304133498000_34.42.13892.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.12.025"},{"key":"2023041304133498000_34.42.13892.51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008843"},{"key":"2023041304133498000_34.42.13892.52","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1242\/dev.115.3.673","article-title":"Synaptic basal lamina contains a signal for synapse-specific transcription","volume":"115","author":"Jo","year":"1992","journal-title":"Development"},{"key":"2023041304133498000_34.42.13892.53","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi381"},{"key":"2023041304133498000_34.42.13892.54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2654"},{"key":"2023041304133498000_34.42.13892.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.002"},{"key":"2023041304133498000_34.42.13892.56","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.5.761"},{"key":"2023041304133498000_34.42.13892.57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610822104"},{"key":"2023041304133498000_34.42.13892.58","doi-asserted-by":"publisher","DOI":"10.1038\/nn2053"},{"key":"2023041304133498000_34.42.13892.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.03.004"},{"key":"2023041304133498000_34.42.13892.60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801683105"},{"key":"2023041304133498000_34.42.13892.61","doi-asserted-by":"publisher","DOI":"10.1038\/35074025"},{"key":"2023041304133498000_34.42.13892.62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.04.003"},{"key":"2023041304133498000_34.42.13892.63","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.08.013"},{"key":"2023041304133498000_34.42.13892.64","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00783-3"},{"key":"2023041304133498000_34.42.13892.65","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1523\/JNEUROSCI.20-10-03663.2000","article-title":"From plaque to pretzel: fold formation and acetylcholine receptor loss at the developing neuromuscular junction","volume":"20","author":"Marques","year":"2000","journal-title":"J Neurosci"},{"key":"2023041304133498000_34.42.13892.66","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1242\/dev.124.19.3909","article-title":"Integrins mediate adhesion to agrin and modulate agrin signaling","volume":"124","author":"Martin","year":"1997","journal-title":"Development"},{"key":"2023041304133498000_34.42.13892.67","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4038-11.2011"},{"key":"2023041304133498000_34.42.13892.68","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq110"},{"key":"2023041304133498000_34.42.13892.69","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1132-4"},{"key":"2023041304133498000_34.42.13892.70","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1523\/JNEUROSCI.03-03-00644.1983","article-title":"Fine structural distribution of acetylcholine receptors at developing mouse neuromuscular junctions","volume":"3","author":"Matthews-Bellinger","year":"1983","journal-title":"J Neurosci"},{"key":"2023041304133498000_34.42.13892.71","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1990.055.01.041"},{"key":"2023041304133498000_34.42.13892.72","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1002\/j.1460-2075.1996.tb00622.x","article-title":"AChR phosphorylation and aggregation induced by an agrin fragment that lacks the binding domain for \u03b1-dystroglycan","volume":"15","author":"Meier","year":"1996","journal-title":"EMBO J"},{"key":"2023041304133498000_34.42.13892.73","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.1523\/JNEUROSCI.17-17-06534.1997","article-title":"Neural agrin induces ectopic postsynaptic specializations in innervated muscle fibers","volume":"17","author":"Meier","year":"1997","journal-title":"J Neurosci"},{"key":"2023041304133498000_34.42.13892.74","doi-asserted-by":"publisher","DOI":"10.1038\/35095054"},{"key":"2023041304133498000_34.42.13892.75","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210865200"},{"key":"2023041304133498000_34.42.13892.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.06.010"},{"key":"2023041304133498000_34.42.13892.77","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000233837.79459.40"},{"key":"2023041304133498000_34.42.13892.78","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0932"},{"key":"2023041304133498000_34.42.13892.79","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(02)02282-1"},{"key":"2023041304133498000_34.42.13892.80","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33372"},{"key":"2023041304133498000_34.42.13892.81","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt578"},{"key":"2023041304133498000_34.42.13892.82","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.115.6.1685"},{"key":"2023041304133498000_34.42.13892.83","doi-asserted-by":"publisher","DOI":"10.1038\/88414"},{"key":"2023041304133498000_34.42.13892.84","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.145.4.911"},{"key":"2023041304133498000_34.42.13892.85","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6194-7"},{"key":"2023041304133498000_34.42.13892.86","doi-asserted-by":"publisher","DOI":"10.1038\/35035124"},{"key":"2023041304133498000_34.42.13892.87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1976.tb47678.x"},{"key":"2023041304133498000_34.42.13892.88","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.04.018"},{"key":"2023041304133498000_34.42.13892.89","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806719200"},{"key":"2023041304133498000_34.42.13892.90","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20714"},{"key":"2023041304133498000_34.42.13892.91","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08482.x"},{"key":"2023041304133498000_34.42.13892.92","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8800com"},{"key":"2023041304133498000_34.42.13892.93","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.025"},{"key":"2023041304133498000_34.42.13892.94","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90090-Z"},{"key":"2023041304133498000_34.42.13892.95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046663"},{"key":"2023041304133498000_34.42.13892.96","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000065882.63904.53"},{"key":"2023041304133498000_34.42.13892.97","doi-asserted-by":"publisher","DOI":"10.1038\/35097557"},{"key":"2023041304133498000_34.42.13892.98","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1345-04.2004"},{"key":"2023041304133498000_34.42.13892.99","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66039"},{"key":"2023041304133498000_34.42.13892.100","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.04.005"},{"key":"2023041304133498000_34.42.13892.101","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21545"},{"key":"2023041304133498000_34.42.13892.102","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.002"},{"key":"2023041304133498000_34.42.13892.103","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880180103"},{"key":"2023041304133498000_34.42.13892.104","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90247-3"},{"key":"2023041304133498000_34.42.13892.105","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90246-5"},{"key":"2023041304133498000_34.42.13892.106","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029976"},{"key":"2023041304133498000_34.42.13892.107","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90462-6"},{"key":"2023041304133498000_34.42.13892.108","doi-asserted-by":"publisher","DOI":"10.1038\/35035117"},{"key":"2023041304133498000_34.42.13892.109","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1113\/jphysiol.1990.sp018094","article-title":"Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro","volume":"425","author":"Thayer","year":"1990","journal-title":"J Physiol"},{"key":"2023041304133498000_34.42.13892.110","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201366"},{"key":"2023041304133498000_34.42.13892.111","doi-asserted-by":"publisher","DOI":"10.1038\/nn1128"},{"key":"2023041304133498000_34.42.13892.112","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02696"},{"key":"2023041304133498000_34.42.13892.113","doi-asserted-by":"publisher","DOI":"10.1038\/35035110"},{"key":"2023041304133498000_34.42.13892.114","doi-asserted-by":"publisher","DOI":"10.1242\/dev.038711"},{"key":"2023041304133498000_34.42.13892.115","doi-asserted-by":"publisher","DOI":"10.1242\/dev.080705"},{"key":"2023041304133498000_34.42.13892.116","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.04.033"},{"key":"2023041304133498000_34.42.13892.117","doi-asserted-by":"publisher","DOI":"10.1038\/nature11348"},{"key":"2023041304133498000_34.42.13892.118","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4691-06.2007"},{"key":"2023041304133498000_34.42.13892.119","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.10.006"},{"key":"2023041304133498000_34.42.13892.120","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-5-7"},{"key":"2023041304133498000_34.42.13892.121","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.2393"},{"key":"2023041304133498000_34.42.13892.122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091816"},{"key":"2023041304133498000_34.42.13892.123","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.279307"},{"key":"2023041304133498000_34.42.13892.124","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4130-07.2008"},{"key":"2023041304133498000_34.42.13892.125","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.12.004"},{"key":"2023041304133498000_34.42.13892.126","doi-asserted-by":"publisher","DOI":"10.1101\/gad.180885.111"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.1733-14.2014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T22:15:37Z","timestamp":1681424137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.1733-14.2014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,15]]},"references-count":126,"journal-issue":{"issue":"42","published-online":{"date-parts":[[2014,10,15]]},"published-print":{"date-parts":[[2014,10,15]]}},"alternative-id":["10.1523\/JNEUROSCI.1733-14.2014"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.1733-14.2014","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,15]]}}}