{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:48:27Z","timestamp":1792727307402,"version":"4.5.0"},"reference-count":33,"publisher":"Society for Neuroscience","issue":"35","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:p>We investigated the effects of rolipram, a selective cAMP phosphodiesterase (PDE) inhibitor, on late plastic events during functional CA1 plasticity<jats:italic>in vitro<\/jats:italic>in rat hippocampal slices. We present data showing that an early form of long-term potentiation (LTP) (early-LTP) that normally decays within 2-3 hr can be converted to a lasting LTP (late-LTP) if rolipram is applied during tetanization. This rolipram-reinforced LTP (RLTP) was NMDA receptor and protein synthesis dependent. cAMP formation in region CA1 during late-LTP requires dopaminergic receptor activity (Frey et al., 1989, 1990). Thus, we studied whether RLTP was influenced by inhibitors of the D<jats:sub>1<\/jats:sub>\/D<jats:sub>5<\/jats:sub>receptor. Application of the specific D<jats:sub>1<\/jats:sub>\/D<jats:sub>5<\/jats:sub>antagonist<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"SCH23390\" ext-link-type=\"genpept\" xlink:type=\"simple\">SCH23390<\/jats:ext-link>(0.1 \u03bc<jats:sc>m<\/jats:sc>) did not prevent RLTP, suggesting that the phosphodiesterase inhibitor acts downstream of the D<jats:sub>1<\/jats:sub>\/D<jats:sub>5<\/jats:sub>receptors. We also studied whether rolipram can interact with processes of synaptic tagging, because RLTP was also dependent on protein synthesis, similar to late-LTP. Inhibition of PDE and subsequent induction of RLTP in one synaptic population were able to transform early-LTP into late-LTP in a second, independent synaptic population of the same neurons. This supports our hypothesis that cAMP-dependent processes are directly involved in the synthesis of plasticity-related proteins.<\/jats:p>","DOI":"10.1523\/jneurosci.1796-04.2004","type":"journal-article","created":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T17:52:45Z","timestamp":1094061165000},"page":"7740-7744","source":"Crossref","is-referenced-by-count":102,"title":["The Type IV-Specific Phosphodiesterase Inhibitor Rolipram and Its Effect on Hippocampal Long-Term Potentiation and Synaptic Tagging"],"prefix":"10.1523","volume":"24","author":[{"given":"Sheeja","family":"Navakkode","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreedharan","family":"Sajikumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julietta 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