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The present study investigated the effects of repeated AMPH exposure on the neuromodulatory actions of dopamine (DA) on BLA\u2013mPFC circuitry and cognitive\/emotional processing mediated by these circuits. Rats received five AMPH (2 mg\/kg) or saline injections (controls) over 10 d, followed by 2\u20134 week drug washout.<jats:italic>In vivo<\/jats:italic>neurophysiological extracellular recordings in urethane-anesthetized rats were used to obtain data from mPFC neurons that were either inhibited or excited by BLA stimulation. In controls, acute AMPH attenuated BLA-evoked inhibitory or excitatory responses; these effects were mimicked by selective D<jats:sub>2<\/jats:sub>or D<jats:sub>1<\/jats:sub>agonists, respectively. However, in AMPH-treated rats, the ability of these dopaminergic manipulations to modulate BLA-driven decreases\/increases in mPFC activity was abolished. Repeated AMPH also blunted the excitatory effects of ventral tegmental area stimulation on mPFC neural firing. Behavioral studies assessed the effect of repeated AMPH on decision making with conditioned punishment, a process mediated by BLA\u2013mPFC circuitry and mesocortical DA. These treatments impaired the ability of rats to use conditioned aversive stimuli (footshock-associated cue) to guide the direction of instrumental responding. Collectively, these data suggest that repeated AMPH exposure can lead to persistent disruption of dopaminergic modulation of BLA\u2013mPFC circuitry, which may underlie impairments in cognitive\/emotional processing observed in stimulant abusers. 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