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LLDs are followed by a long refractory period, limiting LLD generation to \u223c1 Hz. LLD production does not appear to involve either intrinsic voltage-activated or metabotropic mechanisms. The initiation of LLDs requires activation of non-NMDA but not NMDA receptors. Dual recordings from the apical dendrites and somata of mitral cells show that LLDs are generated in the distal portion of the apical dendrite, most likely in the glomerulus. The rising phase of LLDs shows characteristics of polyneuronal input, including a high variability and sensitivity to charge screening. Paired recordings from adjacent mitral cells suggest that LLDs occur synchronously only in cells whose apical dendrites ramify in the same glomerulus. These findings suggest that LLDs involve recurrent, intraglomerular dendrodendritic interactions among M\/T cells.<\/jats:p>","DOI":"10.1523\/jneurosci.20-05-02011.2000","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T14:25:25Z","timestamp":1522938325000},"page":"2011-2021","source":"Crossref","is-referenced-by-count":169,"title":["Long-Lasting Depolarizations in Mitral Cells of the Rat Olfactory Bulb"],"prefix":"10.1523","volume":"20","author":[{"given":"Greg C.","family":"Carlson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Shipley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaf","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2023041302442608000_20.5.2011.1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a073625"},{"key":"2023041302442608000_20.5.2011.2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/72.2.186"},{"key":"2023041302442608000_20.5.2011.3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1152\/jn.1999.81.1.15","article-title":"Current-source density analysis in the rat olfactory bulb: laminar distribution of kainate\/AMPA- and NMDA-receptor-mediated currents.","volume":"81","author":"Aroniadou-Anderjaska","year":"1999","journal-title":"J Neurophysiol"},{"key":"2023041302442608000_20.5.2011.4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/jn.1999.82.1.489","article-title":"Dendrodendritic recurrent excitation in mitral cells of the rat olfactory bulb.","volume":"82","author":"Aroniadou-Anderjaska","year":"1999","journal-title":"J Neurophysiol"},{"key":"2023041302442608000_20.5.2011.5","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1097\/00001756-199607290-00033","article-title":"Excitatory synapses in the glomerular triad of frog olfactory bulb in vitro.","volume":"7","author":"Bardoni","year":"1996","journal-title":"NeuroReport"},{"key":"2023041302442608000_20.5.2011.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80043-9"},{"key":"2023041302442608000_20.5.2011.7","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90919-7"},{"key":"2023041302442608000_20.5.2011.8","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90914-2"},{"key":"2023041302442608000_20.5.2011.9","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903070106"},{"key":"2023041302442608000_20.5.2011.10","doi-asserted-by":"crossref","unstructured":"Cajal SR (1995) Histology of the nervous system. 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