{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:52:59Z","timestamp":1794012779132,"version":"4.8.0"},"reference-count":79,"publisher":"Society for Neuroscience","issue":"39","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2013,9,25]]},"abstract":"<jats:p>Disabled-1 (Dab1) is an adaptor protein that is an obligate effector of the Reelin signaling pathway, and is critical for neuronal migration and dendrite outgrowth during development. Components of the Reelin pathway are highly expressed during development, but also continue to be expressed in the adult brain. Here we investigated in detail the expression pattern of Dab1 in the postnatal and adult forebrain, and determined that it is expressed in excitatory as well as inhibitory neurons. Dab1 was found to be localized in different cellular compartments, including the soma, dendrites, presynaptic and postsynaptic structures. Mice that are deficient in Dab1, Reelin, or the Reelin receptors ApoER2 and VLDLR exhibit severely perturbed brain cytoarchitecture, limiting the utility of these mice for investigating the role of this signaling pathway in the adult brain. In this study, we developed an adult forebrain-specific and excitatory neuron-specific conditional knock-out mouse line, and demonstrated that Dab1 is a critical regulator of synaptic function and hippocampal-dependent associative and spatial learning. These dramatic abnormalities were accompanied by a reduction in dendritic spine size, and defects in basal and plasticity-induced Akt and ERK1\/2 signaling. Deletion of Dab1 led to no obvious changes in neuronal positioning, dendrite morphology, spine density, or synaptic composition. Collectively, these data conclusively demonstrate an important role for Reelin-Dab1 signaling in the adult forebrain, and underscore the importance of this pathway in learning and memory.<\/jats:p>","DOI":"10.1523\/jneurosci.2010-13.2013","type":"journal-article","created":{"date-parts":[[2013,9,25]],"date-time":"2013-09-25T16:47:08Z","timestamp":1380127628000},"page":"15652-15668","source":"Crossref","is-referenced-by-count":96,"title":["Dab1 Is Required for Synaptic Plasticity and Associative Learning"],"prefix":"10.1523","volume":"33","author":[{"given":"Justin","family":"Trotter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gum Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana M.","family":"Kazdoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Crowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Domogauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Mahoney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santos J.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin J.","family":"Weeber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"D'Arcangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2013,9,25]]},"reference":[{"key":"2023041304070569000_33.39.15652.1","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1523\/JNEUROSCI.18-19-07779.1998","article-title":"Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse","volume":"18","author":"Alc\u00e1ntara","year":"1998","journal-title":"J Neurosci"},{"key":"2023041304070569000_33.39.15652.2","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.01.1.1.010.2007"},{"key":"2023041304070569000_33.39.15652.3","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0b013e32809c2f75"},{"key":"2023041304070569000_33.39.15652.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(03)00295-X"},{"key":"2023041304070569000_33.39.15652.5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209205200"},{"key":"2023041304070569000_33.39.15652.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.07.007"},{"key":"2023041304070569000_33.39.15652.7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4566-05.2006"},{"key":"2023041304070569000_33.39.15652.8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306416200"},{"key":"2023041304070569000_33.39.15652.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2007.06.006"},{"key":"2023041304070569000_33.39.15652.10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005505"},{"key":"2023041304070569000_33.39.15652.11","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01320"},{"key":"2023041304070569000_33.39.15652.12","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1951-05.2005"},{"key":"2023041304070569000_33.39.15652.13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3758-06.2007"},{"key":"2023041304070569000_33.39.15652.14","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4477-10.2011"},{"key":"2023041304070569000_33.39.15652.15","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19991001)58:1<88::AID-JNR9>3.0.CO;2-R"},{"key":"2023041304070569000_33.39.15652.16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0074-7742(05)71016-3","article-title":"The reeler mouse: anatomy of a mutant","volume":"17","author":"D'Arcangelo","year":"2005","journal-title":"Int Rev Neurobiol"},{"key":"2023041304070569000_33.39.15652.17","doi-asserted-by":"publisher","DOI":"10.1038\/374719a0"},{"key":"2023041304070569000_33.39.15652.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80860-0"},{"key":"2023041304070569000_33.39.15652.19","doi-asserted-by":"publisher","DOI":"10.1038\/385070a0"},{"key":"2023041304070569000_33.39.15652.20","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<133::AID-GENE10>3.0.CO;2-V"},{"key":"2023041304070569000_33.39.15652.21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017203"},{"key":"2023041304070569000_33.39.15652.22","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5622-11.2012"},{"key":"2023041304070569000_33.39.15652.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.12.018"},{"key":"2023041304070569000_33.39.15652.24","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1746-10.2010"},{"key":"2023041304070569000_33.39.15652.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.01.003"},{"key":"2023041304070569000_33.39.15652.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00206-X"},{"key":"2023041304070569000_33.39.15652.27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05470.x"},{"key":"2023041304070569000_33.39.15652.28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02694.x"},{"key":"2023041304070569000_33.39.15652.29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1772-07.2007"},{"key":"2023041304070569000_33.39.15652.30","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.11.1061"},{"key":"2023041304070569000_33.39.15652.31","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1523\/JNEUROSCI.14-08-05028.1994","article-title":"TEA elicits two distinct potentiations of synaptic transmission in the CA1 region of the hippocampal slice","volume":"14","author":"Hanse","year":"1994","journal-title":"J Neurosci"},{"key":"2023041304070569000_33.39.15652.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.05.006"},{"key":"2023041304070569000_33.39.15652.33","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5516-05.2006"},{"key":"2023041304070569000_33.39.15652.34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3984-10.2011"},{"key":"2023041304070569000_33.39.15652.35","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3233\/JAD-2012-112069","article-title":"Reelin depletion is an early phenomenon of Alzheimer's pathology","volume":"30","author":"Herring","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"2023041304070569000_33.39.15652.36","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80861-2"},{"key":"2023041304070569000_33.39.15652.37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1404-12.2013"},{"key":"2023041304070569000_33.39.15652.38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M900141200"},{"key":"2023041304070569000_33.39.15652.39","doi-asserted-by":"publisher","DOI":"10.1038\/39607"},{"key":"2023041304070569000_33.39.15652.40","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.6.643"},{"key":"2023041304070569000_33.39.15652.41","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00608-4"},{"key":"2023041304070569000_33.39.15652.42","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.66"},{"key":"2023041304070569000_33.39.15652.43","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2816"},{"key":"2023041304070569000_33.39.15652.44","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00928-07"},{"key":"2023041304070569000_33.39.15652.45","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5264-08.2009"},{"key":"2023041304070569000_33.39.15652.46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06913.x"},{"key":"2023041304070569000_33.39.15652.47","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0530-0"},{"key":"2023041304070569000_33.39.15652.48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07433.x"},{"key":"2023041304070569000_33.39.15652.49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051614698"},{"key":"2023041304070569000_33.39.15652.50","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/srep01103","article-title":"Feedback mechanism in depolarization-induced sustained activation of extracellular signal-regulated kinase in the hippocampus","volume":"3","author":"Maharana","year":"2013","journal-title":"Sci Rep"},{"key":"2023041304070569000_33.39.15652.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2011.01.003"},{"key":"2023041304070569000_33.39.15652.52","doi-asserted-by":"publisher","DOI":"10.1038\/nn736"},{"key":"2023041304070569000_33.39.15652.53","doi-asserted-by":"publisher","DOI":"10.1038\/nature02617"},{"key":"2023041304070569000_33.39.15652.54","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00819-5"},{"key":"2023041304070569000_33.39.15652.55","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1917-08.2008"},{"key":"2023041304070569000_33.39.15652.56","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-7-25"},{"key":"2023041304070569000_33.39.15652.57","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90329-1"},{"key":"2023041304070569000_33.39.15652.58","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01306-X"},{"key":"2023041304070569000_33.39.15652.59","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4323-08.2008"},{"key":"2023041304070569000_33.39.15652.60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3221"},{"key":"2023041304070569000_33.39.15652.61","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5284-09.2010"},{"key":"2023041304070569000_33.39.15652.62","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00869.2006"},{"key":"2023041304070569000_33.39.15652.63","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2561-06.2006"},{"key":"2023041304070569000_33.39.15652.64","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2005.11.001"},{"key":"2023041304070569000_33.39.15652.65","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1242\/dev.125.18.3719","article-title":"Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain","volume":"125","author":"Rice","year":"1998","journal-title":"Development"},{"key":"2023041304070569000_33.39.15652.66","doi-asserted-by":"publisher","DOI":"10.1101\/lm.2153511"},{"key":"2023041304070569000_33.39.15652.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.07.020"},{"key":"2023041304070569000_33.39.15652.68","doi-asserted-by":"publisher","DOI":"10.1038\/39601"},{"key":"2023041304070569000_33.39.15652.69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3245"},{"key":"2023041304070569000_33.39.15652.70","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj147"},{"key":"2023041304070569000_33.39.15652.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.04.001"},{"key":"2023041304070569000_33.39.15652.72","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80782-5"},{"key":"2023041304070569000_33.39.15652.73","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3135-11.2011"},{"key":"2023041304070569000_33.39.15652.74","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81826-7"},{"key":"2023041304070569000_33.39.15652.75","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4548-06.2007"},{"key":"2023041304070569000_33.39.15652.76","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.05.050"},{"key":"2023041304070569000_33.39.15652.77","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32042"},{"key":"2023041304070569000_33.39.15652.78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205147200"},{"key":"2023041304070569000_33.39.15652.79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2010.11.009"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.2010-13.2013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T21:49:33Z","timestamp":1681422573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.2010-13.2013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,25]]},"references-count":79,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2013,9,25]]},"published-print":{"date-parts":[[2013,9,25]]}},"alternative-id":["10.1523\/JNEUROSCI.2010-13.2013"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.2010-13.2013","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,25]]}}}