{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:21:44Z","timestamp":1792131704967,"version":"4.4.0"},"reference-count":56,"publisher":"Society for Neuroscience","issue":"44","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2016,11,2]]},"abstract":"<jats:p>Feeding behavior is orchestrated by neural circuits primarily residing in the hypothalamus and hindbrain. However, the relative influence of cognitive and emotional brain circuits to the feeding circuitry in the hypothalamus and hindbrain remains unclear. Here, using the cell-type selectivity of genetic methods, circuit mapping, and behavior assays, we sought to decipher neural circuits emanating from the septal nucleus to the lateral hypothalamus (LH) that contribute to neural regulation of food intake in mice. We found that chemogenetic and optogenetic activation of septal vesicular GABA transporter (vGAT)-containing neurons or their projections in the LH reduced food intake in mice. Consistently, chemogenetic inhibition of septal vGAT neurons increased food intake. Furthermore, we investigated a previously unknown neural circuit originating from septal vGAT neurons to a subset of vGAT neurons in the LH, an area involved in homeostatic and hedonic control of energy states. Collectively, our data reveal an inhibitory septohypothalamic feeding circuit that might serve as a therapeutic target for the treatment of eating disorders such as anorexia nervosa.<\/jats:p><jats:p><jats:bold>SIGNIFICANCE STATEMENT<\/jats:bold>Our results demonstrate that top-down projections from the septum to the hypothalamus control food intake negatively. Given the known role for both of these brain regions in the control of feeding and emotion-related behaviors, these findings reveal previously unknown neural circuitry that is likely implicated in emotional aspects of food intake and provide new insights into the development of therapeutic targets for the treatment of eating disorders.<\/jats:p>","DOI":"10.1523\/jneurosci.2042-16.2016","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T16:49:02Z","timestamp":1478105342000},"page":"11185-11195","source":"Crossref","is-referenced-by-count":94,"title":["An Inhibitory Septum to Lateral Hypothalamus Circuit That Suppresses Feeding"],"prefix":"10.1523","volume":"36","author":[{"given":"Patrick","family":"Sweeney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-840X","authenticated-orcid":false,"given":"Yunlei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2016,11,2]]},"reference":[{"key":"2023041803215664000_36.44.11185.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6773(76)92118-0"},{"key":"2023041803215664000_36.44.11185.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.06.014"},{"key":"2023041803215664000_36.44.11185.3","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-77-18766"},{"key":"2023041803215664000_36.44.11185.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.040"},{"key":"2023041803215664000_36.44.11185.5","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2739"},{"key":"2023041803215664000_36.44.11185.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700293104"},{"key":"2023041803215664000_36.44.11185.7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3044-06.2007"},{"key":"2023041803215664000_36.44.11185.8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3799-15.2016"},{"key":"2023041803215664000_36.44.11185.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.04.051"},{"key":"2023041803215664000_36.44.11185.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.002"},{"key":"2023041803215664000_36.44.11185.11","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00009"},{"key":"2023041803215664000_36.44.11185.12","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20499"},{"key":"2023041803215664000_36.44.11185.13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1152\/ajplegacy.1952.172.1.162","article-title":"Increase of food intake induced by electrical stimulation of the lateral hypothalamus","volume":"172","author":"Delgado","year":"1953","journal-title":"Am J Physiol"},{"key":"2023041803215664000_36.44.11185.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2013.09.022"},{"key":"2023041803215664000_36.44.11185.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.037"},{"key":"2023041803215664000_36.44.11185.16","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(82)90281-5"},{"key":"2023041803215664000_36.44.11185.17","doi-asserted-by":"publisher","DOI":"10.1126\/science.705344"},{"key":"2023041803215664000_36.44.11185.18","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11190"},{"key":"2023041803215664000_36.44.11185.19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241812"},{"key":"2023041803215664000_36.44.11185.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.026"},{"key":"2023041803215664000_36.44.11185.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.07.002"},{"key":"2023041803215664000_36.44.11185.22","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(79)90306-8"},{"key":"2023041803215664000_36.44.11185.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.07.035"},{"key":"2023041803215664000_36.44.11185.24","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12798"},{"key":"2023041803215664000_36.44.11185.25","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.304"},{"key":"2023041803215664000_36.44.11185.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.04.035"},{"key":"2023041803215664000_36.44.11185.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.003"},{"key":"2023041803215664000_36.44.11185.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.038"},{"key":"2023041803215664000_36.44.11185.29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00496.2013"},{"key":"2023041803215664000_36.44.11185.30","doi-asserted-by":"publisher","DOI":"10.1038\/nn1891"},{"key":"2023041803215664000_36.44.11185.31","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0855-15.2015"},{"key":"2023041803215664000_36.44.11185.32","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00009-X"},{"key":"2023041803215664000_36.44.11185.33","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4561-11.2012"},{"key":"2023041803215664000_36.44.11185.34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071812-161125"},{"key":"2023041803215664000_36.44.11185.35","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.295"},{"key":"2023041803215664000_36.44.11185.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.04.009"},{"key":"2023041803215664000_36.44.11185.37","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.213"},{"key":"2023041803215664000_36.44.11185.38","doi-asserted-by":"crossref","unstructured":"Sparks P.D. LeDoux J.E (2000) in The behavioral neuroscience of the septal region, The septal complex as seen through the context of fear, ed Numan R (Springer, New York), pp 234\u2013269.","DOI":"10.1007\/978-1-4612-1302-4_10"},{"key":"2023041803215664000_36.44.11185.39","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1152\/jn.1940.3.6.538","article-title":"Forebrain and rage reactions","volume":"3","author":"Spiegel","year":"1940","journal-title":"J Neurophysiol"},{"key":"2023041803215664000_36.44.11185.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.04.008"},{"key":"2023041803215664000_36.44.11185.41","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-15.2016"},{"key":"2023041803215664000_36.44.11185.42","doi-asserted-by":"publisher","DOI":"10.1159\/000369072"},{"key":"2023041803215664000_36.44.11185.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.04.006"},{"key":"2023041803215664000_36.44.11185.44","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90692-3"},{"key":"2023041803215664000_36.44.11185.45","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4220"},{"key":"2023041803215664000_36.44.11185.46","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10188"},{"key":"2023041803215664000_36.44.11185.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2016.03.013"},{"key":"2023041803215664000_36.44.11185.48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00460.2015"},{"key":"2023041803215664000_36.44.11185.49","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00008"},{"key":"2023041803215664000_36.44.11185.50","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3217"},{"key":"2023041803215664000_36.44.11185.51","doi-asserted-by":"publisher","DOI":"10.1016\/0364-7722(81)90028-X"},{"key":"2023041803215664000_36.44.11185.52","doi-asserted-by":"publisher","DOI":"10.1126\/science.566469"},{"key":"2023041803215664000_36.44.11185.53","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3720-14.2015"},{"key":"2023041803215664000_36.44.11185.54","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229534"},{"key":"2023041803215664000_36.44.11185.55","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.04.002"},{"key":"2023041803215664000_36.44.11185.56","unstructured":"Yeomans JS (1982) in The neural basis of feeding and reward, The cells and axons mediating medial forebrain bundle reward, eds Hoebel BG Novin D (Haernstitute, Location), pp 405\u2013417."}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.2042-16.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T10:45:11Z","timestamp":1681814711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.2042-16.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,2]]},"references-count":56,"journal-issue":{"issue":"44","published-online":{"date-parts":[[2016,11,2]]},"published-print":{"date-parts":[[2016,11,2]]}},"alternative-id":["10.1523\/JNEUROSCI.2042-16.2016"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.2042-16.2016","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,2]]}}}