{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:32:49Z","timestamp":1791419569995,"version":"4.3.3"},"reference-count":44,"publisher":"Society for Neuroscience","issue":"40","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2012,10,3]]},"abstract":"<jats:p>Glucagon-like peptide-1 (GLP-1) is an endogenous intestinal peptide that enhances glucose-stimulated insulin secretion. Its natural cleavage product GLP-1(9-36)<jats:sup>amide<\/jats:sup>possesses distinct properties and does not affect insulin secretion. Here we report that pretreatment of hippocampal slices with GLP-1(9-36)<jats:sup>amide<\/jats:sup>prevented impaired long-term potentiation (LTP) and enhanced long-term depression induced by exogenous amyloid \u03b2 peptide A\u03b2<jats:sub>(1\u201342)<\/jats:sub>. Similarly, hippocampal LTP impairments in amyloid precursor protein\/presenilin 1 (APP\/PS1) mutant mice that model Alzheimer's disease (AD) were prevented by GLP-1(9-36)<jats:sup>amide<\/jats:sup>. In addition, treatment of APP\/PS1 mice with GLP-1(9-36)<jats:sup>amide<\/jats:sup>at an age at which they display impaired spatial and contextual fear memory resulted in a reversal of their memory defects. At the molecular level, GLP-1(9-36)<jats:sup>amide<\/jats:sup>reduced elevated levels of mitochondrial-derived reactive oxygen species and restored dysregulated Akt\u2013glycogen synthase kinase-3\u03b2 signaling in the hippocampus of APP\/PS1 mice. Our findings suggest that GLP-1(9-36)<jats:sup>amide<\/jats:sup>treatment may have therapeutic potential for AD and other diseases associated with cognitive dysfunction.<\/jats:p>","DOI":"10.1523\/jneurosci.2107-12.2012","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T20:44:02Z","timestamp":1349297042000},"page":"13701-13708","source":"Crossref","is-referenced-by-count":89,"title":["Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer's Disease Model Mice"],"prefix":"10.1523","volume":"32","author":[{"given":"Tao","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueliang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph 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