{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:59:26Z","timestamp":1792738766544,"version":"4.5.0"},"reference-count":52,"publisher":"Society for Neuroscience","issue":"41","license":[{"start":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T00:00:00Z","timestamp":1271203200000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2009,10,14]]},"abstract":"<jats:p>Retinotopic mapping is a basic feature of visual system organization, but its role in processing visual information is unknown. Mutant mice lacking the \u03b22 subunit of nicotinic acetylcholine receptor have imprecise maps in both visual cortex (V1) and the superior colliculus (SC) due to the disruption of spontaneous retinal activity during development. Here, we use behavioral and physiological approaches to study their visual functions. We find that \u03b22\u2212\/\u2212 mice fail to track visual stimuli moving along the nasotemporal axis in a subcortical optomotor behavior, but track normally along the dorsoventral axis. In contrast, these mice display normal acuity along both axes in the visual water task, a behavioral test of cortical functions. Consistent with the behavioral results, we find that V1 neurons in \u03b22\u2212\/\u2212 mice have normal response properties, while SC neurons have disrupted receptive fields, including enlarged structure and decreased direction and orientation selectivity along the nasotemporal axis. The subcortical-specific deficits indicate that retinotopic map disruption has different impacts on the development of functional properties in V1 and the SC.<\/jats:p>","DOI":"10.1523\/jneurosci.2128-09.2009","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T16:12:59Z","timestamp":1255536779000},"page":"12909-12918","source":"Crossref","is-referenced-by-count":60,"title":["Direction-Specific Disruption of Subcortical Visual Behavior and Receptive Fields in Mice Lacking the \u03b22 Subunit of Nicotinic Acetylcholine Receptor"],"prefix":"10.1523","volume":"29","author":[{"given":"Lupeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krsna V.","family":"Rangarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney 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