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Additionally, Myo5a inhibition led to Nrp1 accumulation within the Golgi apparatus and a significant reduction in its surface expression. Remarkably, overexpression of Nrp1 or VLDLR fully rescued the terminal translocation defects and dendritic abnormalities caused by Myo5a inhibition, demonstrating that Myo5a-dependent Nrp1 trafficking underlies proper Reelin receptor availability during this process. Overall, these results reveal a pivotal Myo5a\u2013Nrp1 trafficking pathway that governs the final stage of neuronal migration, offering a molecular mechanism for the spatial and temporal regulation of receptor dynamics essential for precise cortical layering.<\/jats:p>","DOI":"10.1523\/jneurosci.2137-25.2026","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:55:24Z","timestamp":1787594124000},"page":"e2137252026","update-policy":"https:\/\/doi.org\/10.1523\/jneurosci.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Myosin Va Regulates Terminal Translocation in the Neocortex by Controlling the Trafficking of 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