{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:24:10Z","timestamp":1790195050638,"version":"4.1.0"},"reference-count":56,"publisher":"Society for Neuroscience","issue":"36","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2014,9,3]]},"abstract":"<jats:p>\n                    Sensory nerve fibers differ not only with respect to their sensory modalities and conduction velocities, but also in their relative roles for pain hypersensitivity. It is presently largely unknown which types of sensory afferents contribute to various forms of neuropathic and inflammatory pain hypersensitivity. Vesicular glutamate transporter 3-positive (VGluT3\n                    <jats:sup>+<\/jats:sup>\n                    ) primary afferents, for example, have been implicated in mechanical hypersensitivity after inflammation, but their role in neuropathic pain remains under debate. Here, we investigated a possible etiology-dependent contribution of VGluT3\n                    <jats:sup>+<\/jats:sup>\n                    fibers to mechanical and cold hypersensitivity in different models of inflammatory and neuropathic pain. In addition to\n                    <jats:italic>VGluT3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, we used\n                    <jats:italic>VGluT3-channelrhodopsin 2<\/jats:italic>\n                    mice to selectively stimulate VGluT3\n                    <jats:sup>+<\/jats:sup>\n                    sensory afferents by blue light, and to assess light-evoked behavior in freely moving mice. We show that\n                    <jats:italic>VGluT3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice develop reduced mechanical hypersensitivity upon carrageenan injection. Both mechanical and cold hypersensitivity were reduced in\n                    <jats:italic>VGluT3<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice in neuropathic pain evoked by the chemotherapeutic oxaliplatin, but not in the chronic constriction injury (CCI) model of the sciatic nerve. Further, we provide direct evidence that, despite not mediating painful stimuli in naive mice, activation of VGluT3\n                    <jats:sup>+<\/jats:sup>\n                    sensory fibers by light elicits pain behavior in the oxaliplatin but not the CCI model. Immunohistochemical and electrophysiological data support a role of transient receptor potential melastatin 8-mediated facilitation of synaptic strength at the level of the dorsal horn as an underlying mechanism. Together, we demonstrate that VGluT3\n                    <jats:sup>+<\/jats:sup>\n                    fibers contribute in an etiology-dependent manner to the development of mechano-cold hypersensitivity.\n                  <\/jats:p>","DOI":"10.1523\/jneurosci.2157-14.2014","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T18:27:11Z","timestamp":1410200831000},"page":"12015-12028","source":"Crossref","is-referenced-by-count":58,"title":["VGluT3\n                    <sup>+<\/sup>\n                    Primary Afferents Play Distinct Roles in Mechanical and Cold Hypersensitivity Depending on Pain Etiology"],"prefix":"10.1523","volume":"34","author":[{"given":"Peter","family":"Draxler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke Doris","family":"Honsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Forsthuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Hadschieff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Sandk\u00fchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2014,9,3]]},"reference":[{"key":"2023041304125408000_34.36.12015.1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00095-V"},{"key":"2023041304125408000_34.36.12015.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00667-1"},{"key":"2023041304125408000_34.36.12015.3","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-1-36"},{"key":"2023041304125408000_34.36.12015.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032709"},{"key":"2023041304125408000_34.36.12015.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.01.006"},{"key":"2023041304125408000_34.36.12015.6","doi-asserted-by":"publisher","DOI":"10.1038\/nature05910"},{"key":"2023041304125408000_34.36.12015.7","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"2023041304125408000_34.36.12015.8","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/jn.1969.32.6.1025","article-title":"Response 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