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We used paired recording in olfactory bulb slices and two-photon targeted patch-clamp recording<jats:italic>in vivo<\/jats:italic>to characterize the properties and connections of a genetically identified population of PG cells expressing enhanced yellow fluorescent protein (EYFP) under the control of the Kv3.1 potassium channel promoter. Kv3.1\u2013EYFP<jats:sup>+<\/jats:sup>PG cells are axonless and monoglomerular neurons that constitute \u223c30% of all PG cells and include calbindin-expressing neurons. They respond to an olfactory nerve stimulation with a short barrage of excitatory inputs mediated by mitral, tufted, and external tufted cells, and, in turn, they indiscriminately release GABA onto principal neurons. They are activated by even the weakest olfactory nerve input or by the discharge of a single principal neuron in slices and at each respiration cycle in anesthetized mice. They participate in a fast-onset intraglomerular lateral inhibition between principal neurons from the same glomerulus, a circuit that reduces the firing rate and promotes spike timing variability in mitral cells. Recordings in other PG cell subtypes suggest that this pathway predominates in generating glomerular inhibition. Intraglomerular lateral inhibition may play a key role in olfactory processing by reducing the similarity of principal cells discharge in response to the same incoming input.<\/jats:p>","DOI":"10.1523\/jneurosci.2181-14.2015","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T16:33:23Z","timestamp":1426091603000},"page":"4319-4331","source":"Crossref","is-referenced-by-count":68,"title":["Intraglomerular Lateral Inhibition Promotes Spike Timing Variability in Principal Neurons of the Olfactory Bulb"],"prefix":"10.1523","volume":"35","author":[{"given":"Marion","family":"Najac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Sanz 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