{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:44:42Z","timestamp":1791125082128,"version":"4.1.0"},"reference-count":29,"publisher":"Society for Neuroscience","issue":"1","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p>Mouse<jats:italic>Zic<\/jats:italic>genes encode zinc finger proteins and are expressed in the developing and mature CNS. Reduced expression of<jats:italic>Zic2<\/jats:italic>in mice results in spina bifida and holoprosencephaly. However, the disruption of<jats:italic>Zic1<\/jats:italic>, a strong homolog of<jats:italic>Zic2<\/jats:italic>that has an overlapping expression pattern, results in cerebellar malformation with no apparent abnormalities in the forebrain or in posterior neuropore closure. Here we revealed that<jats:italic>Zic2<\/jats:italic>and<jats:italic>Zic1<\/jats:italic>cooperatively control cerebellar development by regulating neuronal differentiation. Both<jats:italic>Zic1<\/jats:italic>and<jats:italic>Zic2<\/jats:italic>are expressed in the precursor cells of the granule neuron and the neurons in cerebellar nuclei. Mice carrying one mutated<jats:italic>Zic1<\/jats:italic>allele together with one mutated<jats:italic>Zic2<\/jats:italic>allele (<jats:italic>Zic1<\/jats:italic><jats:sup><jats:italic>+\/\u2212<\/jats:italic><\/jats:sup><jats:italic>Zic2<jats:sup>+\/kd<\/jats:sup><\/jats:italic>) showed a marked cerebellar folial abnormality similar to, but distinct from that found in mice homozygous for the<jats:italic>Zic1<\/jats:italic>mutation (<jats:italic>Zic1<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic>). The<jats:italic>Zic1<jats:sup>+\/\u2212<\/jats:sup>Zic2<jats:sup>+\/kd<\/jats:sup><\/jats:italic>cerebellum is missing a lobule in the anterior vermis and has a truncation of the most posterior lobule. Expression of transverse zonal markers is shifted anteriorly in the developing cerebellum, indicating that the anterior part of the cerebellum is poorly developed. Abnormalities in the developing<jats:italic>Zic1<jats:sup>+\/\u2212<\/jats:sup>Zic2<jats:sup>+\/kd<\/jats:sup><\/jats:italic>cerebellum share the following features with those of the<jats:italic>Zic1<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic>cerebellum: a preceding reduction of cell proliferation in the anterior external germinal layer, a reduction in<jats:italic>cyclin D1<\/jats:italic>expression, and enhanced expression of the mitosis inhibitors<jats:italic>p27<\/jats:italic>and<jats:italic>p16<\/jats:italic>, and enhancement of<jats:italic>Wnt7a<\/jats:italic>expression. These results indicate that<jats:italic>Zic1<\/jats:italic>and<jats:italic>Zic2<\/jats:italic>may have very similar functions in the regulation of cerebellar development.<\/jats:p>","DOI":"10.1523\/jneurosci.22-01-00218.2002","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:15:54Z","timestamp":1522887354000},"page":"218-225","source":"Crossref","is-referenced-by-count":131,"title":["<i>Zic2<\/i>Controls Cerebellar Development in Cooperation with<i>Zic1<\/i>"],"prefix":"10.1523","volume":"22","author":[{"given":"Jun","family":"Aruga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Mikoshiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2002,1,1]]},"reference":[{"key":"2023041302502629000_22.1.218.1","unstructured":"Altman J Bayer SA (1997) Comparative anatomy of the cerebellum, an evolutionally perspective. 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The central nervous system of vertebrates (Nieuwenhuys R, ten Donkelaar HJ, Nicholson C) (Springer, Berlin), pp 1724\u20131753."}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.22-01-00218.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T14:46:02Z","timestamp":1681397162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.22-01-00218.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2002,1,1]]},"published-print":{"date-parts":[[2002,1,1]]}},"alternative-id":["10.1523\/JNEUROSCI.22-01-00218.2002"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.22-01-00218.2002","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,1]]}}}