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In this study, we demonstrate that a newly developed test for determining average efferent system strength can predict intersubject variations in acoustic injury. In addition, the intersubject variability in cochlear expression of the \u03b19 subunit of the nicotinic acetylcholine receptor was found to be proportional to an animals average efferent strength. Therefore, the inter-animal variability in the \u03b19-containing acetylcholine receptor expression may be one mechanism contributing to the inter-animal variability in acoustic injury.<\/jats:p>","DOI":"10.1523\/jneurosci.22-10-04241.2002","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T23:40:38Z","timestamp":1522885238000},"page":"4241-4247","source":"Crossref","is-referenced-by-count":39,"title":["Variation in Inter-Animal Susceptibility to Noise Damage Is Associated with \u03b19 Acetylcholine Receptor Subunit Expression Level"],"prefix":"10.1523","volume":"22","author":[{"given":"Anne E.","family":"Luebke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2002,5,15]]},"reference":[{"key":"2023041302513397000_22.10.4241.1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/newbio231222a0","article-title":"Acetylcholine mimics crossed olivocochlear bundle stimulation.","volume":"231","author":"Bobbin","year":"1971","journal-title":"Nat New Biol"},{"key":"2023041302513397000_22.10.4241.2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00206099209072897","article-title":"Effects of contralateral white noise on click-evoked emissions in normal and sensorineural ears: towards an exploration of the medial olivocochlear system.","volume":"31","author":"Collet","year":"1992","journal-title":"Audiology"},{"key":"2023041302513397000_22.10.4241.3","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90555-X"},{"key":"2023041302513397000_22.10.4241.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051622798"},{"key":"2023041302513397000_22.10.4241.5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.12-03-00800.1992"},{"key":"2023041302513397000_22.10.4241.6","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1995.0188"},{"key":"2023041302513397000_22.10.4241.7","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1991.0065"},{"key":"2023041302513397000_22.10.4241.8","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.6.3095"},{"key":"2023041302513397000_22.10.4241.9","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(93)90068-C"},{"key":"2023041302513397000_22.10.4241.10","doi-asserted-by":"publisher","DOI":"10.1121\/1.414956"},{"key":"2023041302513397000_22.10.4241.11","unstructured":"Luebke AE, Foster PK, Stagner BB (2001) A multi-frequency method for determining cochlear efferent activity. 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