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Neurosci."],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:p>Age-related hearing loss, or presbyacusis, is a common degenerative disorder affecting communication and quality of life for millions of older adults. Multiple pathophysiologic manifestations, along with many cellular and molecular alterations, have been linked to presbyacusis; however, the initial events and causal factors have not been clearly established. Comparisons of the transcriptome in the lateral wall (LW) with other cochlear regions in a mouse model (of both sexes) of \u201cnormal\u201d age-related hearing loss revealed that early pathophysiological alterations in the stria vascularis (SV) are associated with increased macrophage activation and a molecular signature indicative of inflammaging, a common form of immune dysfunction. Structure-function correlation analyses in mice across the lifespan showed that the age-dependent increase in macrophage activation in the stria vascularis is associated with a decline in auditory sensitivity. High-resolution imaging analysis of macrophage activation in middle-aged and aged mouse and human cochleas, along with transcriptomic analysis of age-dependent changes in mouse cochlear macrophage gene expression, support the hypothesis that aberrant macrophage activity is an important contributor to age-dependent strial dysfunction, cochlear pathology, and hearing loss. Thus, this study highlights the SV as a primary site of age-related cochlear degeneration and aberrant macrophage activity and dysregulation of the immune system as early indicators of age-related cochlear pathology and hearing loss. Importantly, novel new imaging methods described here now provide a means to analyze human temporal bones in a way that had not previously been feasible and thereby represent a significant new tool for otopathological evaluation.<\/jats:p><jats:p><jats:bold>SIGNIFICANCE STATEMENT<\/jats:bold>Age-related hearing loss is a common neurodegenerative disorder affecting communication and quality of life. Current interventions (primarily hearing aids and cochlear implants) offer imperfect and often unsuccessful therapeutic outcomes. Identification of early pathology and causal factors is crucial for the development of new treatments and early diagnostic tests. Here, we find that the SV, a nonsensory component of the cochlea, is an early site of structural and functional pathology in mice and humans that is characterized by aberrant immune cell activity. We also establish a new technique for evaluating cochleas from human temporal bones, an important but understudied area of research because of a lack of well-preserved human specimens and difficult tissue preparation and processing approaches.<\/jats:p>","DOI":"10.1523\/jneurosci.2234-22.2023","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T17:56:02Z","timestamp":1685728562000},"page":"5057-5075","source":"Crossref","is-referenced-by-count":60,"title":["The Stria Vascularis in Mice and Humans Is an Early Site of Age-Related Cochlear Degeneration, Macrophage Dysfunction, and Inflammation"],"prefix":"10.1523","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2210-7856","authenticated-orcid":false,"given":"Hainan","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenyaria V.","family":"Noble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6113-8140","authenticated-orcid":false,"given":"Jeremy L.","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4593-5590","authenticated-orcid":false,"given":"Jeffrey A.","family":"Rumschlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyreek R.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby L.","family":"Storm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Eckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy R.","family":"Dubno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"2023081806050817000_43.27.5057.1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1106"},{"key":"2023081806050817000_43.27.5057.2","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"2023081806050817000_43.27.5057.3","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.3390\/cells10102761","article-title":"Cochlear inflammaging in relation to ion channels and mitochondrial functions","volume":"10","author":"Bazard","year":"2021","journal-title":"Cells"},{"key":"2023081806050817000_43.27.5057.4","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3390\/antiox10091351","article-title":"Dual-specificity phosphatase 1 (DUSP1) has a central role in redox homeostasis and inflammation in the mouse cochlea","volume":"10","author":"Berm\u00fadez-Mu\u00f1oz","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"2023081806050817000_43.27.5057.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.05.014"},{"key":"2023081806050817000_43.27.5057.6","unstructured":"Bohne BA (1971) Scar formation in the inner ear following acoustical injury; sequence of changes from early signs of damage to healed lesion. 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