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Importantly, \u0394FosB also enhances the degree of effort mice will exert to maintain self-administration of higher doses on a progressive ratio schedule of reinforcement, whereas levels of cocaine intake are not altered on less demanding fixed-ratio schedules. Acquisition and extinction of behavior reinforced by food pellets is not altered in \u0394FosB-overexpressing mice, indicating that \u0394FosB does not alter the capacity to learn an instrumental response or cause response perseveration in the absence of reinforcement. These data suggest that accumulation of \u0394FosB contributes to drug addiction by increasing the incentive properties of cocaine, an effect that could increase the risk for relapse long after cocaine use ceases.<\/jats:p>","DOI":"10.1523\/jneurosci.23-06-02488.2003","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T23:25:04Z","timestamp":1523575504000},"page":"2488-2493","source":"Crossref","is-referenced-by-count":197,"title":["Striatal Cell Type-Specific Overexpression of \u0394FosB Enhances Incentive for Cocaine"],"prefix":"10.1523","volume":"23","author":[{"given":"Christina 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