{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:19:59Z","timestamp":1793193599011,"version":"4.5.0"},"reference-count":58,"publisher":"Society for Neuroscience","issue":"42","license":[{"start":{"date-parts":[[2007,4,18]],"date-time":"2007-04-18T00:00:00Z","timestamp":1176854400000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2006,10,18]]},"abstract":"<jats:p>Functional magnetic resonance imaging was used to study patients with chronic neuropathic pain involving the maxillary region (V2) of the trigeminal nerve in patients with spontaneous pain and evoked pain to brush (allodynia). Patients underwent two functional scans (2\u20133 months apart) with mechanical and thermal stimuli applied to the affected region of V2 and to the mirror site in the unaffected contralateral V2 region, as well as bilaterally to the mandibular (V3) division. Patients were stimulated with brush, noxious cold, and noxious heat. Significant changes were observed in regions within and outside the primary trigeminal sensory pathway. Stimulation to the affected (neuropathic) side resulted in predominantly frontal region and basal ganglia activation compared with the control side. The differences were consistent with the allodynia to brush and cold. A region of interest-based analysis of the trigeminal sensory pathway revealed patterns of activation that differentiated between the affected and unaffected sides and that were particular to each stimulus. Activation in the spinal trigeminal nucleus was constant in location for all pain stimuli. Activation in other brainstem nuclei also showed differences in the blood oxygenation level-dependent signal for the affected versus the unaffected side. Thus, sensory processing in patients with trigeminal neuropathic pain is associated with distinct activation patterns consistent with sensitization within and outside of the primary sensory pathway.<\/jats:p>","DOI":"10.1523\/jneurosci.2305-06.2006","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T16:27:57Z","timestamp":1161188877000},"page":"10646-10657","source":"Crossref","is-referenced-by-count":172,"title":["Trigeminal Neuropathic Pain Alters Responses in CNS Circuits to Mechanical (Brush) and Thermal (Cold and Heat) Stimuli"],"prefix":"10.1523","volume":"26","author":[{"given":"Lino","family":"Becerra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Bazes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Gostic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Sherman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Gostic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam","family":"Pendse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Moulton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Scrivani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Keith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Chizh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Borsook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"393","published-online":{"date-parts":[[2006,10,18]]},"reference":[{"key":"2023041303212917000_26.42.10646.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-9091(02)00003-7"},{"key":"2023041303212917000_26.42.10646.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.09.054"},{"key":"2023041303212917000_26.42.10646.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.020"},{"key":"2023041303212917000_26.42.10646.4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/00207458808985739","article-title":"The basal ganglia and pain","volume":"41","author":"Barker","year":"1988","journal-title":"Int J Neurosci"},{"key":"2023041303212917000_26.42.10646.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00533-5"},{"key":"2023041303212917000_26.42.10646.6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1152\/jn.1992.68.2.551","article-title":"Nucleus centralis of the amygdala and the globus pallidus ventralis: electrophysiological evidence for an involvement in pain processes","volume":"68","author":"Bernard","year":"1992","journal-title":"J Neurophysiol"},{"key":"2023041303212917000_26.42.10646.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00157-4"},{"key":"2023041303212917000_26.42.10646.8","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh094"},{"key":"2023041303212917000_26.42.10646.9","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00249.2003"},{"key":"2023041303212917000_26.42.10646.10","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/00001756-199804200-00011","article-title":"Acute plasticity in the human somatosensory cortex following amputation","volume":"9","author":"Borsook","year":"1998","journal-title":"NeuroReport"},{"key":"2023041303212917000_26.42.10646.11","doi-asserted-by":"crossref","first-page":"7897","DOI":"10.1523\/JNEUROSCI.23-21-07897.2003","article-title":"Specific and somatotopic functional magnetic resonance imaging activation in the trigeminal ganglion by brush and noxious heat","volume":"23","author":"Borsook","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303212917000_26.42.10646.12","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20085"},{"key":"2023041303212917000_26.42.10646.13","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1016\/j.expneurol.2003.07.006","article-title":"Insights into the pathophysiology of neuropathic pain through functional brain imaging","volume":"184","author":"Casey","year":"2003","journal-title":"Exp Neurol"},{"key":"2023041303212917000_26.42.10646.14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11910-005-0003-6","article-title":"Trigeminal neuralgia: diagnosis and treatment","volume":"5","author":"Cheshire","year":"2005","journal-title":"Curr Neurol Neurosci Rep"},{"key":"2023041303212917000_26.42.10646.15","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00172-B"},{"key":"2023041303212917000_26.42.10646.16","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1152\/jn.1999.82.4.1934","article-title":"Pain intensity processing within the human brain: a bilateral, distributed mechanism","volume":"82","author":"Coghill","year":"1999","journal-title":"J Neurophysiol"},{"key":"2023041303212917000_26.42.10646.17","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.1523\/JNEUROSCI.22-18-08183.2002","article-title":"Somatotopic activation in the human trigeminal pain pathway","volume":"22","author":"DaSilva","year":"2002","journal-title":"J Neurosci"},{"key":"2023041303212917000_26.42.10646.18","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl016"},{"key":"2023041303212917000_26.42.10646.19","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1100-05.2005"},{"key":"2023041303212917000_26.42.10646.20","unstructured":"Duvernoy HM Bourgouin P Cabanis EA Cattin F Guyot J Iba-Zizen MT Maeder P Parratte B Tatu L Vuillier F Vannson JL (1995) in Surface, structure, vascularization, and three-dimensional anatomy with MRI, The human brain stem and cerebellum, ed Duvernoy HM (Springer\/Wein, New York), Ed 2, pp 35\u201340."},{"key":"2023041303212917000_26.42.10646.21","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199811000-00055"},{"key":"2023041303212917000_26.42.10646.22","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1523\/JNEUROSCI.14-02-00599.1994","article-title":"Input\u2013output organization of the sensorimotor striatum in the squirrel monkey","volume":"14","author":"Flaherty","year":"1994","journal-title":"J Neurosci"},{"key":"2023041303212917000_26.42.10646.23","doi-asserted-by":"publisher","DOI":"10.1177\/104839509901000401"},{"key":"2023041303212917000_26.42.10646.24","doi-asserted-by":"publisher","DOI":"10.1007\/s100060050178"},{"key":"2023041303212917000_26.42.10646.25","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-002-0604-1"},{"key":"2023041303212917000_26.42.10646.26","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000149798.93498.7c"},{"key":"2023041303212917000_26.42.10646.27","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00015-K"},{"key":"2023041303212917000_26.42.10646.28","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1152\/physrev.1994.74.3.509","article-title":"Motor function of the cerebellorubrospinal system","volume":"74","author":"Keifer","year":"1994","journal-title":"Physiol Rev"},{"key":"2023041303212917000_26.42.10646.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00310-3"},{"key":"2023041303212917000_26.42.10646.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.04.016"},{"key":"2023041303212917000_26.42.10646.31","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1523\/JNEUROSCI.14-03-01756.1994","article-title":"Differential ability of human cutaneous nociceptors to signal mechanical pain and to produce vasodilatation","volume":"14","author":"Koltzenburg","year":"1994","journal-title":"J Neurosci"},{"key":"2023041303212917000_26.42.10646.32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.14219\/jada.archive.1993.0200","article-title":"Estimated prevalence and distribution of reported orofacial pain in the United States","volume":"124","author":"Lipton","year":"1993","journal-title":"J Am Dent Assoc"},{"key":"2023041303212917000_26.42.10646.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00767-5"},{"key":"2023041303212917000_26.42.10646.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.049"},{"key":"2023041303212917000_26.42.10646.35","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000200961.49114.39"},{"key":"2023041303212917000_26.42.10646.36","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1523\/JNEUROSCI.13-06-02689.1993","article-title":"Patterns of increased brain activity indicative of pain in a rat model of peripheral mononeuropathy","volume":"13","author":"Mao","year":"1993","journal-title":"J Neurosci"},{"key":"2023041303212917000_26.42.10646.37","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90413-X"},{"key":"2023041303212917000_26.42.10646.38","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70130-9"},{"key":"2023041303212917000_26.42.10646.39","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20763"},{"key":"2023041303212917000_26.42.10646.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.06.006"},{"key":"2023041303212917000_26.42.10646.41","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007778"},{"key":"2023041303212917000_26.42.10646.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.01.006"},{"key":"2023041303212917000_26.42.10646.43","first-page":"117","article-title":"Ventral tegmental (A10) system: neurobiology","volume":"434","author":"Oades","year":"1987","journal-title":"1. Anatomy and connectivity. Brain Res"},{"key":"2023041303212917000_26.42.10646.44","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01071.x"},{"key":"2023041303212917000_26.42.10646.45","first-page":"492","article-title":"A generalized mixture modeling approach applied to the problem of thresholding fMRI statistical maps","volume":"32","author":"Pendse","year":"2006","journal-title":"Soc Neurosci Abstr"},{"key":"2023041303212917000_26.42.10646.46","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1212\/01.WNL.0000144177.61125.85","article-title":"An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain","volume":"63","author":"Peyron","year":"2004","journal-title":"Neurology"},{"key":"2023041303212917000_26.42.10646.47","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00368-8"},{"key":"2023041303212917000_26.42.10646.48","first-page":"648","article-title":"Neurophysiology and cognitive functions of the striatum","volume":"150","author":"Rolls","year":"1994","journal-title":"Rev Neurol (Paris)"},{"key":"2023041303212917000_26.42.10646.49","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70027-X"},{"key":"2023041303212917000_26.42.10646.50","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(95)90055-1"},{"key":"2023041303212917000_26.42.10646.51","doi-asserted-by":"publisher","DOI":"10.1007\/s002219900279"},{"key":"2023041303212917000_26.42.10646.52","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01224-6"},{"key":"2023041303212917000_26.42.10646.53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1747-4477.2000.tb00146.x","article-title":"Neuropathic orofacial pain part 1\u2013prevalence and pathophysiology","volume":"26","author":"Vickers","year":"2000","journal-title":"Aust Endod J"},{"key":"2023041303212917000_26.42.10646.54","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00004691-199701000-00002","article-title":"Neuroanatomy of the pain system and of the pathways that modulate pain","volume":"14","author":"Willis","year":"1997","journal-title":"J Clin Neurophysiol"},{"key":"2023041303212917000_26.42.10646.55","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1212\/WNL.57.10.1817","article-title":"Experimental brush-evoked allodynia activates posterior parietal cortex","volume":"57","author":"Witting","year":"2001","journal-title":"Neurology"},{"key":"2023041303212917000_26.42.10646.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.10.034"},{"key":"2023041303212917000_26.42.10646.57","unstructured":"Woolf CJ Borsook D Koltzenburg M (2003) in Pain, current understanding, emerging therapies, and novel approaches to drug discovery, Mechanistic approach to the diagnosis of pain, eds Bountra C Munglani R Schmidt WK (Dekker, New York), pp 1\u20138."},{"key":"2023041303212917000_26.42.10646.58","doi-asserted-by":"crossref","unstructured":"Worsley KJ (2001) Statistical analysis of activation images (Oxford UP, Oxford).","DOI":"10.1093\/acprof:oso\/9780192630711.003.0014"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.2305-06.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T17:41:18Z","timestamp":1681407678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.2305-06.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,18]]},"references-count":58,"journal-issue":{"issue":"42","published-online":{"date-parts":[[2006,10,18]]},"published-print":{"date-parts":[[2006,10,18]]}},"alternative-id":["10.1523\/JNEUROSCI.2305-06.2006"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.2305-06.2006","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,18]]}}}