{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:26:19Z","timestamp":1774409179292,"version":"3.50.1"},"reference-count":60,"publisher":"Society for Neuroscience","issue":"39","license":[{"start":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T00:00:00Z","timestamp":1237852800000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2008,9,24]]},"abstract":"<jats:p>Neuromodulatory substances have profound effects on the two motor patterns generated by the adult crustacean stomatogastric ganglion (STG), the gastric mill rhythm and the pyloric rhythm. Developmentally regulated changes in the modulatory functions of neuromodulators could therefore play an important role in the maturation of the output from the developing STG. We compared the effects of neuromodulators on isolated embryonic and adult STG of the lobster,<jats:italic>Homarus americanus<\/jats:italic>. Bath application of Val<jats:sup>1<\/jats:sup>-SIFamide, a peptide whose expression is different in embryos and adults, activated different neuron classes in embryos and adults.<jats:italic>Cancer borealis<\/jats:italic>tachykinin-related peptide 1a, a peptide that does not appear in the terminals of modulatory neurons in the STG until after embryonic development, also produced different motor patterns in embryos and adults. In contrast, red pigment concentrating hormone, a peptide with a similar distribution in the STNS across development, produced similar motor patterns in embryonic and adult STG. Proctolin, serotonin, and allatostatin were also physiologically active on the isolated embryonic STG. Together, these results demonstrate that receptors to many neuromodulators are present and functional on STG neurons before the motor patterns of the stomatogastric nervous system are mature. Moreover, neuromodulator responses change during development, perhaps contributing to the maturation of the output from the stomatogastric nervous system.<\/jats:p>","DOI":"10.1523\/jneurosci.2328-08.2008","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T16:28:23Z","timestamp":1222273703000},"page":"9828-9839","source":"Crossref","is-referenced-by-count":31,"title":["Developmental Regulation of Neuromodulator Function in the Stomatogastric Ganglion of the Lobster,<i>Homarus americanus<\/i>"],"prefix":"10.1523","volume":"28","author":[{"given":"Kristina J.","family":"Rehm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine E.","family":"Deeg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve","family":"Marder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2008,9,24]]},"reference":[{"key":"2023041303341522000_28.39.9828.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2004.12.005"},{"key":"2023041303341522000_28.39.9828.2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00004.2006"},{"key":"2023041303341522000_28.39.9828.3","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21169"},{"key":"2023041303341522000_28.39.9828.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.05154.x"},{"key":"2023041303341522000_28.39.9828.5","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1523\/JNEUROSCI.15-08-05703.1995","article-title":"Functional differentiation of adult neural circuits from a single embryonic network","volume":"15","author":"Casasnovas","year":"1995","journal-title":"J Neurosci"},{"key":"2023041303341522000_28.39.9828.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.10.049"},{"key":"2023041303341522000_28.39.9828.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.11.020"},{"key":"2023041303341522000_28.39.9828.8","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20932"},{"key":"2023041303341522000_28.39.9828.9","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00049.2002"},{"key":"2023041303341522000_28.39.9828.10","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1523\/JNEUROSCI.23-07-02851.2003","article-title":"Developmental loss of synchronous spontaneous activity in the mouse retina is independent of visual experience","volume":"23","author":"Demas","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303341522000_28.39.9828.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00075-8"},{"key":"2023041303341522000_28.39.9828.12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05209.x"},{"key":"2023041303341522000_28.39.9828.13","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4406-06.2007"},{"key":"2023041303341522000_28.39.9828.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80724-2"},{"key":"2023041303341522000_28.39.9828.15","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980928)399:3<289::AID-CNE1>3.0.CO;2-X"},{"key":"2023041303341522000_28.39.9828.16","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990607)408:3<335::AID-CNE3>3.0.CO;2-W"},{"key":"2023041303341522000_28.39.9828.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00341-5"},{"key":"2023041303341522000_28.39.9828.18","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.097238"},{"key":"2023041303341522000_28.39.9828.19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2307\/1542337","article-title":"Embryonic development of the American lobster (Homarus americanus): quantitative staging and characterization of an embryonic molt cycle","volume":"180","author":"Helluy","year":"1991","journal-title":"Biol Bull"},{"key":"2023041303341522000_28.39.9828.20","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903540208"},{"key":"2023041303341522000_28.39.9828.21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.112910"},{"key":"2023041303341522000_28.39.9828.22","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990607)408:3<318::AID-CNE2>3.0.CO;2-S"},{"key":"2023041303341522000_28.39.9828.23","doi-asserted-by":"publisher","DOI":"10.1038\/45238"},{"key":"2023041303341522000_28.39.9828.24","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0172-05.2005"},{"key":"2023041303341522000_28.39.9828.25","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1002\/j.1460-2075.1991.tb04885.x","article-title":"Cloning, heterologous expression and developmental regulation of a Drosophila receptor for tachykinin-like peptides","volume":"10","author":"Li","year":"1991","journal-title":"EMBO J"},{"key":"2023041303341522000_28.39.9828.26","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.031905.161516"},{"key":"2023041303341522000_28.39.9828.27","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1949"},{"key":"2023041303341522000_28.39.9828.28","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/S0021-9258(18)48429-3","article-title":"NKD, a developmentally regulated tachykinin receptor in Drosophila","volume":"267","author":"Monnier","year":"1992","journal-title":"J Biol Chem"},{"key":"2023041303341522000_28.39.9828.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.06.009"},{"key":"2023041303341522000_28.39.9828.30","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2004"},{"key":"2023041303341522000_28.39.9828.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00399-3"},{"key":"2023041303341522000_28.39.9828.32","doi-asserted-by":"crossref","first-page":"9575","DOI":"10.1523\/JNEUROSCI.23-29-09575.2003","article-title":"Ontogeny of the pre-B\u00f6tzinger complex in perinatal rats","volume":"23","author":"Pagliardini","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303341522000_28.39.9828.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.11.050"},{"key":"2023041303341522000_28.39.9828.34","doi-asserted-by":"crossref","first-page":"10154","DOI":"10.1523\/JNEUROSCI.23-31-10154.2003","article-title":"Peptidergic activation of locomotor pattern generators in the neonatal spinal cord","volume":"23","author":"Pearson","year":"2003","journal-title":"J Neurosci"},{"key":"2023041303341522000_28.39.9828.35","unstructured":"Percival DB Walden AT (1993) Spectral analysis for physical applications: multitaper and conventional univariate techniques (Cambridge UP, Cambridge, UK)."},{"key":"2023041303341522000_28.39.9828.36","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)00026-4"},{"key":"2023041303341522000_28.39.9828.37","doi-asserted-by":"publisher","DOI":"10.1038\/nn1352"},{"key":"2023041303341522000_28.39.9828.38","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10331"},{"key":"2023041303341522000_28.39.9828.39","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10767"},{"key":"2023041303341522000_28.39.9828.40","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1523\/JNEUROSCI.06-08-02187.1986","article-title":"Ontogeny of substance P receptor binding sites in rat brain","volume":"6","author":"Quirion","year":"1986","journal-title":"J Neurosci"},{"key":"2023041303341522000_28.39.9828.41","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490220311"},{"key":"2023041303341522000_28.39.9828.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphysparis.2007.05.009"},{"key":"2023041303341522000_28.39.9828.43","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00042.2008"},{"key":"2023041303341522000_28.39.9828.44","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00539.2002"},{"key":"2023041303341522000_28.39.9828.45","unstructured":"Richards KS (2000) Development and modulation of the stomatogastric motor patterns of the lobster, Homarus americanus . PhD thesis (Brandeis University)."},{"key":"2023041303341522000_28.39.9828.46","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4695(200007)44:1<31::AID-NEU4>3.0.CO;2-F"},{"key":"2023041303341522000_28.39.9828.47","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1152\/jn.1999.82.4.2006","article-title":"Maturation of lobster stomatogastric ganglion rhythmic activity","volume":"82","author":"Richards","year":"1999","journal-title":"J Neurophysiol"},{"key":"2023041303341522000_28.39.9828.48","doi-asserted-by":"publisher","DOI":"10.2108\/zsj.20.533"},{"key":"2023041303341522000_28.39.9828.49","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(00)00024-0"},{"key":"2023041303341522000_28.39.9828.50","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1995.0010"},{"key":"2023041303341522000_28.39.9828.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.07.018"},{"key":"2023041303341522000_28.39.9828.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.05.005"},{"key":"2023041303341522000_28.39.9828.53","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1523\/JNEUROSCI.22-05-01874.2002","article-title":"Colocalized neuropeptides activate a central pattern generator by acting on different circuit targets","volume":"22","author":"Thirumalai","year":"2002","journal-title":"J Neurosci"},{"key":"2023041303341522000_28.39.9828.54","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00397-X"},{"key":"2023041303341522000_28.39.9828.55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05661.x"},{"key":"2023041303341522000_28.39.9828.56","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0328-06.2006"},{"key":"2023041303341522000_28.39.9828.57","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80135-X"},{"key":"2023041303341522000_28.39.9828.58","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90122-8"},{"key":"2023041303341522000_28.39.9828.59","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.01.011"},{"key":"2023041303341522000_28.39.9828.60","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1152\/jn.1993.69.4.1338","article-title":"Changes in serotonin-induced potentials during spinal cord development","volume":"69","author":"Ziskind-Conhaim","year":"1993","journal-title":"J Neurophysiol"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.2328-08.2008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T18:52:12Z","timestamp":1681411932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.2328-08.2008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,24]]},"references-count":60,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2008,9,24]]},"published-print":{"date-parts":[[2008,9,24]]}},"alternative-id":["10.1523\/JNEUROSCI.2328-08.2008"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.2328-08.2008","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,24]]}}}