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Intrastriatal TGF\u03b1 infusion induced significant proliferation, hyperplastic nodules, and substantial migratory waves of nestin-positive progenitor cells from the adult subventricular zone (SVZ) of dopamine-denervated rats. Interestingly, SVZ cells in naive rats displayed proliferation but minimal migration in response to the TGF\u03b1 infusion. The cells in the expanded SVZ accumulated cytoplasmic \u03b2-catenin, indicating activation of classical Wnt signaling. However, no evidence of any neuronal differentiation was found of these recruited progenitor cells anywhere examined in the brain. Consequently, no evidence of dopaminergic (DA) neurogenesis was found in the striatum or substantia nigra in any experimental group, and amphetamine-induced behavioral rotations did not improve. In summary, the cells in the TGF\u03b1-induced migratory cellular wave remain undifferentiated and do not differentiate into midbrain-like DA neurons.<\/jats:p>","DOI":"10.1523\/jneurosci.2344-04.2004","type":"journal-article","created":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T18:03:49Z","timestamp":1097690629000},"page":"8924-8931","source":"Crossref","is-referenced-by-count":131,"title":["Intrastriatal Transforming Growth Factor \u03b1 Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic 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