{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T13:11:19Z","timestamp":1775999479326,"version":"3.50.1"},"reference-count":50,"publisher":"Society for Neuroscience","issue":"48","license":[{"start":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T00:00:00Z","timestamp":1401148800000},"content-version":"vor","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Neurosci."],"published-print":{"date-parts":[[2013,11,27]]},"abstract":"<jats:p>Postural limb reflexes (PLRs) represent a substantial component of the postural system responsible for stabilization of dorsal-side-up trunk orientation in quadrupeds. Spinalization causes spinal shock, that is a dramatic reduction of extensor tone and spinal reflexes, including PLRs. The goal of our study was to determine changes in activity of spinal interneurons, in particular those mediating PLRs, that is caused by spinalization. For this purpose, in decerebrate rabbits, activity of individual interneurons from L5 was recorded during stimulation causing PLRs under two conditions: (1) when neurons received supraspinal influences and (2) when these influences were temporarily abolished by a cold block of spike propagation in spinal pathways at T12 (\u201creversible spinalization\u201d; RS). The effect of RS, that is a dramatic reduction of PLRs, was similar to the effect of surgical spinalization. In the examined population of interneurons (<jats:italic>n<\/jats:italic>= 199), activity of 84% of them correlated with PLRs, suggesting that they contribute to PLR generation. RS affected differently individual neurons: the mean frequency decreased in 67% of neurons, increased in 15%, and did not change in 18%. Neurons with different RS effects were differently distributed across the spinal cord: 80% of inactivated neurons were located in the intermediate area and ventral horn, whereas 50% of nonaffected neurons were located in the dorsal horn. We found a group of neurons that were coactivated with extensors during PLRs before RS and exhibited a dramatic (&gt;80%) decrease in their activity during RS. We suggest that these neurons are responsible for reduction of extensor tone and postural reflexes during spinal shock.<\/jats:p>","DOI":"10.1523\/jneurosci.2394-13.2013","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T17:46:11Z","timestamp":1385574371000},"page":"18987-18998","source":"Crossref","is-referenced-by-count":14,"title":["Effects of Reversible Spinalization on Individual Spinal Neurons"],"prefix":"10.1523","volume":"33","author":[{"given":"Pavel V.","family":"Zelenin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir F.","family":"Lyalka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ju","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigori N.","family":"Orlovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana G.","family":"Deliagina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"393","published-online":{"date-parts":[[2013,11,27]]},"reference":[{"key":"2023041304080997000_33.48.18987.1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(89)90020-4"},{"key":"2023041304080997000_33.48.18987.2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S0317167100020060","article-title":"Neurophysiological changes following spinal cord lesions in man","volume":"2","author":"Ashby","year":"1975","journal-title":"Can J Neurol Sci"},{"key":"2023041304080997000_33.48.18987.3","doi-asserted-by":"crossref","unstructured":"Baldissera F Hultborn H Illert M (1981) in Handbook of physiology, Sec 1, The nervous system, Vol 2, Motor control, Integration in spinal neuronal systems, ed Brooks VB (American Physiological Society, Bethesda, MD), pp 509\u2013595.","DOI":"10.1002\/cphy.cp010212"},{"key":"2023041304080997000_33.48.18987.4","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1152\/ajplegacy.1962.203.6.1113","article-title":"Motoneuron resting potentials in spinal shock","volume":"203","author":"Barnes","year":"1962","journal-title":"Am J Physiol"},{"key":"2023041304080997000_33.48.18987.5","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00590.2003"},{"key":"2023041304080997000_33.48.18987.6","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00946.2003"},{"key":"2023041304080997000_33.48.18987.7","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0034097"},{"key":"2023041304080997000_33.48.18987.8","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.7.773"},{"key":"2023041304080997000_33.48.18987.9","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1152\/jn.2001.85.2.1005","article-title":"Spinal interneurons that receive input from muscle afferents are differentially modulated by dorsolateral descending systems","volume":"85","author":"Chen","year":"2001","journal-title":"J Neurophysiol"},{"key":"2023041304080997000_33.48.18987.10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1123\/mcj.4.4.439","article-title":"Role of different sensory inputs for maintenance of body posture in sitting rat and rabbit","volume":"4","author":"Deliagina","year":"2000","journal-title":"Motor Control"},{"key":"2023041304080997000_33.48.18987.11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00239400","article-title":"The capacity for generation of rhythmic oscillations is distributed in the lumbosacral spinal cord of the cat","volume":"53","author":"Deliagina","year":"1983","journal-title":"Exp Brain Res"},{"key":"2023041304080997000_33.48.18987.12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.104893"},{"key":"2023041304080997000_33.48.18987.13","first-page":"766.14","article-title":"Effect of reversible spinalization on spinal interneurons mediating postural limb reflexes","volume":"35","author":"Deliagina","year":"2009","journal-title":"Soc Neurosci Abstr"},{"key":"2023041304080997000_33.48.18987.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2012.03.002"},{"key":"2023041304080997000_33.48.18987.15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101603"},{"key":"2023041304080997000_33.48.18987.16","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/jn.1990.64.3.767","article-title":"Functional organisation within the medullary reticular formation of the intact unanaesthetized cat. I. Movements evoked by microstimulation","volume":"64","author":"Drew","year":"1990","journal-title":"J Neurophysiol"},{"key":"2023041304080997000_33.48.18987.17","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1152\/jn.1990.64.3.782","article-title":"Functional organisation within the medullary reticular formation of the intact unanaesthetized cat. II. Electromyographic activity evoked by microstimulation","volume":"64","author":"Drew","year":"1990","journal-title":"J Neurophysiol"},{"key":"2023041304080997000_33.48.18987.18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1113\/jphysiol.1959.sp006262","article-title":"Supraspinal control of interneurones mediating spinal reflexes","volume":"147","author":"Eccles","year":"1959","journal-title":"J Physiol"},{"key":"2023041304080997000_33.48.18987.19","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/BF02151565","article-title":"Reticulospinal inhibition of transmission through interneurones of spinal reflex pathways","volume":"15","author":"Engberg","year":"1965","journal-title":"Experientia"},{"key":"2023041304080997000_33.48.18987.20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1113\/jphysiol.1968.sp008402","article-title":"Reticulospinal inhibition of transmission in reflex pathways","volume":"194","author":"Engberg","year":"1968","journal-title":"J Physiol"},{"key":"2023041304080997000_33.48.18987.21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1113\/jphysiol.1968.sp008403","article-title":"Reticulospinal inhibition of interneurones","volume":"194","author":"Engberg","year":"1968","journal-title":"J Physiol"},{"key":"2023041304080997000_33.48.18987.22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1968.tb03834.x"},{"key":"2023041304080997000_33.48.18987.23","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.064022"},{"key":"2023041304080997000_33.48.18987.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(06)57016-5"},{"key":"2023041304080997000_33.48.18987.25","first-page":"340","article-title":"On the organization of the supraspinal inhibitory control of interneurons of various spinal reflex arcs","volume":"97","author":"Holmqvist","year":"1959","journal-title":"Arch Ital Biol"},{"key":"2023041304080997000_33.48.18987.26","first-page":"1","article-title":"Differential supraspinal control of synaptic actions evoked by volleys in the flexion reflex afferents in alpha motoneurones","volume":"186","author":"Holmqvist","year":"1961","journal-title":"Acta Physiol Scand Suppl"},{"key":"2023041304080997000_33.48.18987.27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF00237320","article-title":"The rubrospinal tract. I. Effects on alpha-motoneurons innervating hindlimb muscles in cats","volume":"7","author":"Hongo","year":"1969","journal-title":"Exp Brain Res"},{"key":"2023041304080997000_33.48.18987.28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF00237321","article-title":"The rubrospinal tract. II. Facilitation of interneuronal transmission in reflex paths to motoneurons","volume":"7","author":"Hongo","year":"1969","journal-title":"Exp Brain Res"},{"key":"2023041304080997000_33.48.18987.29","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00041.2012"},{"key":"2023041304080997000_33.48.18987.30","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.050971"},{"key":"2023041304080997000_33.48.18987.31","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1152\/jn.1995.73.3.1181","article-title":"Bilateral labyrinthectomy in the cat: effects on the postural response to translation","volume":"73","author":"Inglis","year":"1995","journal-title":"J Neurophysiol"},{"key":"2023041304080997000_33.48.18987.32","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(92)90024-9"},{"key":"2023041304080997000_33.48.18987.33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0031b.x"},{"key":"2023041304080997000_33.48.18987.34","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/57.4.386"},{"key":"2023041304080997000_33.48.18987.35","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90218.2008"},{"key":"2023041304080997000_33.48.18987.36","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00009.2008"},{"key":"2023041304080997000_33.48.18987.37","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00115.2011"},{"key":"2023041304080997000_33.48.18987.38","first-page":"182.06","article-title":"Spinal neurons contributing to spinal shock","volume":"38","author":"Lyalka","year":"2012","journal-title":"Soc Neurosci Abstr"},{"key":"2023041304080997000_33.48.18987.39","unstructured":"Macpherson JM Fung J Jacob R (1997) in Advances in neurology, Vol 72, Neuronal regeneration, reorganization, and repair, Postural orientation, equilibrium, and the spinal cord, ed Seil FJ (Lippincott Williams and Wilkins, Philadelphia), pp 227\u2013232."},{"key":"2023041304080997000_33.48.18987.40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00230042","article-title":"Effect of reversible dorsal cold block on the persistence of inhibition generated by spinal reflexes","volume":"107","author":"Miller","year":"1995","journal-title":"Exp Brain Res"},{"key":"2023041304080997000_33.48.18987.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.02.011"},{"key":"2023041304080997000_33.48.18987.42","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00575.2009"},{"key":"2023041304080997000_33.48.18987.43","doi-asserted-by":"crossref","unstructured":"Orlovsky GN Deliagina TG Grillner S (1999) Neuronal control of locomotion: from mollusc to man (Oxford UP, Oxford).","DOI":"10.1093\/acprof:oso\/9780198524052.001.0001"},{"key":"2023041304080997000_33.48.18987.44","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90832-E"},{"key":"2023041304080997000_33.48.18987.45","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0115594"},{"key":"2023041304080997000_33.48.18987.46","unstructured":"Shek JW Wen GY Wisniewski HM (1986) Atlas of the rabbit brain and spinal cord (Karger, New York)."},{"key":"2023041304080997000_33.48.18987.47","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.1915.sp001713","article-title":"Observations on reflex responses to single break-shocks","volume":"49","author":"Sherrington","year":"1915","journal-title":"J Physiol"},{"key":"2023041304080997000_33.48.18987.48","doi-asserted-by":"publisher","DOI":"10.1152\/jn.91013.2008"},{"key":"2023041304080997000_33.48.18987.49","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(83)90307-X"},{"key":"2023041304080997000_33.48.18987.50","first-page":"131.09","article-title":"Spinal interneurons mediating postural limb reflexes","volume":"6","author":"Zelenin","year":"2012","journal-title":"FENS Forum"}],"container-title":["The Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1523\/JNEUROSCI.2394-13.2013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T21:54:37Z","timestamp":1681422877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jneurosci.org\/lookup\/doi\/10.1523\/JNEUROSCI.2394-13.2013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,27]]},"references-count":50,"journal-issue":{"issue":"48","published-online":{"date-parts":[[2013,11,27]]},"published-print":{"date-parts":[[2013,11,27]]}},"alternative-id":["10.1523\/JNEUROSCI.2394-13.2013"],"URL":"https:\/\/doi.org\/10.1523\/jneurosci.2394-13.2013","relation":{},"ISSN":["0270-6474","1529-2401"],"issn-type":[{"value":"0270-6474","type":"print"},{"value":"1529-2401","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,27]]}}}